NFL Lines Week 1 | NFL Odds Week 1 | Learn How to Bet NFL Week 1

NFL Lines Week 1: Odds And Lines Comparisons At Major US Sportsbooks

• Football
• NFL

We are finally here, NFL Betting is back.

The 2021 National Football League season is ready to kick off Thursday, September 9 with two national brands: Tom Brady, and the Dallas Cowboys.

The Super Bowl LV champion Tampa Bay Buccaneers (from the new title town USA) will play host to the Cowboys to open the new campaign in the same place the last one ended: Raymond James Stadium.

The odds for Week 1 have been out for a while now, and have been moving as bettors have placed wagers in anticipation of the biggest NFL season yet, quite literally. Remember, there will be 17 games for each team this campaign, and 18 weeks of action (each team gets one bye week).

NFL Odds & NFL Lines Week 1

If you are wondering how to bet on the start of the NFL season, which is just around the corner, here you will see all the NFL odds for Week 1. Undoubtedly, you will also find the most attractive NFL Odds and NFL Lines Week 1.

Without further adieu, it's time to kick off an all-American favorite and the great fun of NFL betting that comes with it. Here are the NFL Odds & NFL lines for Week 1.

Here are your updated NFL Week 1 odds, all in one place. Check back daily to see updates.

For more NFL-related content, picks & prediction. Make sure to check our NFL Picks page.

NFL Week 1 Spreads: Opening vs. Current

Matchup Opening SpreadCurrent Spread
Cowboys at BuccaneersBuccaneers -6Buccaneers -6
Eagles at FalconsFalcons -3Falcons -3.5
Jaguars at TexansJaguars -2Jaguars -2.5
Chargers at WashingtonWashington -1.5Washington -1
Cardinals at TitansTitans -2.5Titans -2.5
Seahawks at ColtsColts -1.5Seahawks -3
Steelers at BillsBills -4.5Bills -6.5
49ers at Lions49ers -6.549ers -7.5
Vikings at BengalsVikings -2.5Vikings -3
Jets at PanthersPanthers -4.5Panthers -4.5
Packers at SaintsPackers -1Packers -2.5
Dolphins at PatriotsPatriots -2.5Patriots -2
Broncos at GiantsBroncos -1Broncos -1
Browns at ChiefsChiefs -6.5Chiefs -6
Bears at RamsRams -6Rams -7
Ravens at RaidersRavens -4.5Ravens -4.5
NFL Week 1 Spreads: Opening vs. Current
  • Dallas Cowboys (0-0) at Tampa Bay Buccaneers (0-0): Bucs -6
  • Philadelphia Eagles (0-0) at Atlanta Falcons (0-0): Falcons -3
  • Pittsburgh Steelers (0-0) at Buffalo Bills (0-0): Bills -4.5
  • New York Jets (0-0) at Carolina Panthers (0-0): Panthers -4.5
  • Minnesota Vikings (0-0) at Cincinnati Bengals (0-0): Vikings -2.5
  • San Francisco 49ers (0-0) at Detroit Lions (0-0): 49ers -6.5
  • Jacksonville Jaguars (0-0) at Houston Texans (0-0): Jags -2
  • Seattle Seahawks (0-0) at Indianapolis Colts (0-0): Colts -1.5
  • Arizona Cardinals (0-0) at Tennessee Titans (0-0): Titans -2.5
  • Los Angeles Chargers (0-0) at Washington Football Team (0-0): WFT -1.5 
  • Cleveland Browns (0-0) at Kansas City Chiefs (0-0): Chiefs -6.5
  • Miami Dolphins (0-0) at New England Patriots (0-0): Pats -2.5 
  • Green Bay Packers (0-0) at New Orleans Saints (0-0): Packers -1
  • Denver Broncos (0-0) at New York Giants (0-0): Broncos -1
  • Chicago Bears (0-0) at Los Angeles Rams (0-0): Rams -6
  • Baltimore Ravens (0-0) at Las Vegas Raiders (0-0): Ravens -4.5

NFL Odds & NFL Lines Week 1 With Analysis

Dallas Cowboys at Tampa Bay Buccaneers (-7.5)

Well, Tom Terrific has done it again: he has led his team to a Super Bowl title. Old news, right? Well, this time, it was the Tampa Bay Buccaneers, and Brady has the band back together again in 2021 to make another run at a seventh title, and third for the Bucs. It was a tough thing to do (bring back the whole team), but they have bought in, and Tampa is the new title town.

The Dallas Cowboys were a mess in 2020, after QB Dak Prescott was lost for the season. A 6-10 finish in the worst division, maybe of all time, should inspire little hope that the Cowboys can come into Raymond James Stadium and pull off an upset. In fact, this game might be more like the Super Bowl, with a blowout in favor of the Bucs. You can read a more in-depth story in our Thursday Night Football Odds & Lines for Succesful Bets page about this contest.

Philadelphia Eagles at Atlanta Falcons (-3.5)

There is little optimism surrounding either of these teams heading into 2021, even though it was not long ago that these franchises were playing in the Super Bowl. Both have over/under win totals that place them below .500 for the season, and each won only four games in 2020.

However, some team is going to win here. Atlanta has TE Kyle Pitts in the fold to help Matt Ryan, and Ryan also has offensive guru Arthur Smith as his new head coach. While the Eagles also have a new coach, and their own new target in Heisman Trophy winner DeVonta Smith, it seems like the Falcons might be able to put up a few more points in this contest.

For more details about the odds in this game, make sure to check our NFL Odds page.

Pittsburgh Steelers at Buffalo Bills (-6.5)

If this was last season, this would have been the marquee matchup of the week. The Steelers went 12-4, while the Bills went 13-3, and both won division titles. But Pittsburgh crashed out of the playoffs early to the Browns in a debacle of a game, while the Bills made a run to the AFC title game, losing to the Chiefs.

Buffalo locked up Josh Allen to the biggest contract in history, and after his near-MVP 2020, comes into 2021 looking to keep building. If this line stays under -7, jump on the Bills.

New York Jets at Carolina Panthers (-4.5)

Look who gets an immediate shot to show his old franchise that Adam Gase was the issue, not him: Sam Darnold. The new Panthers’ quarterback has Christian McCaffrey back in the fold and gets a shot to go out in week one and prove that he is the face of the team.

For the Jets, it probably can’t get worse, right? Two wins in 16 games were embarrassing, but they got a high pick and took a shot on Zach Wilson to lead the offense. Whether or not he is ready to win right away is another story. One potential stat to watch out for here: the Panthers were awful at home (and on the road), going 2-6 as well as 2-6 against the spread. Yikes!

Minnesota Vikings (-3.5) at Cincinnati Bengals

Minnesota was one of the bigger disappointments in the NFL last season, going 7-9 in the NFC North. Much of that was down to the play of the defense, which gave up nearly 30 points per game in 2020. You are not going to be over .500 doing that. Can Patrick Peterson help?

For the Bengals, they will just be happy they don’t have to play one of their AFC North rivals this week: the other three teams in that division combined to go 34-14 in 2020. Joe Burrow’s return should help, as should Joe Mixon’s in the backfield. While not a marquee game, it could be one of the most intriguing.

San Francisco 49ers (-7.5) at Detroit Lions

San Francisco was decimated by injuries in 2020 and went just 6-10 one year after leading Super Bowl LIV in the fourth quarter. The defense is still top five, though, and they now have two quarterbacks ready to go.

What can you say about this Detroit franchise? The Lions went 5-11 in 2020, and have a brutal schedule as well. This looks like a big mismatch, and I will be including the 49ers in any Week 1 parlay.

Jacksonville Jaguars (-2.5) at Houston Texans

The two bottom dwellers of the AFC South meet, but it is the Jaguars that look to have a much brighter future, thanks to Trevor Lawrence under center. With Urban Meyer in as head coach and some weapons around Lawrence, this team could be primed to make a jump from 1-15 to somewhere between 5-7 wins.

The Texans are a mess, and with Tyrod Taylor leading the offense thanks to the off-the-field problems of Deshaun Watson, it might not get better any time soon. I don’t see how you can go with Houston in this game under any circumstances.

Seattle Seahawks (-1.5) at Indianapolis Colts

This is another of the top games of Week 1, with two teams that each won at least 11 games in 2020 battling. It seems like there are a few of these types of encounters in the early Sunday window, which is good for bettors.

Seattle is a little more settled here, especially at quarterback. Russell Wilson has been so good for so long, and he was leading the MVP race for the first half of last year. The Indy QB situation, though, is one that you have to watch all the way up until game time. Carson Wentz looks likely to be back early from his foot surgery, but if he does not play, this line will jump.

Arizona Cardinals at Tennessee Titans (-3)

Julio Jones joins the fray for the Titans, who won the AFC South in 2020. But the offense, led by Derrick Henry (over 2,000 yards rushing in 2020) was not the problem. It was the leaky defense that hampered Tennessee last season.

Arizona will want to come in an exploit that, as the Cardinals look to improve again in 2021. Kyler Murray now has A.J.Green to throw to, as well as DeAndre Hopkins. This is one of my teams to look out for, and a win here on opening week would solidify those feelings. 

Los Angeles Chargers (-1) at Washington Football Team

Another early game banger here, as one of the up-and-coming offenses, collides with one of the best defenses in the NFL. The Chargers are getting a lot of love from the pundits, thanks to the play of Justin Herbert under center.

But this Washington team is a force on defense, led by Chase Young, and it might have gotten better with Jamin Davis and William Jackson. The offense definitely did, with Ryan Fitzpatrick at QB. If you are looking for win totals to back, Washington over 8 is one I would be jumping on now.

Cleveland Browns at Kansas City Chiefs (-6)

We move to the late games, and this one could be a preview of the AFC Championship. Both of these teams won plenty of games in 2020: of course, the Chiefs are the two-time defending AFC champs. But the Browns won their first playoff game since 1994, and come in with plenty of momentum.

Here is an interesting stat for you, that may or may not pertain well to this game. In the last 20 season openers, the Super Bowl loser’s game has gone under 14 times, with five overs and a push. It is 53 here, so that should give you some thought.

Miami Dolphins at New England Patriots (-2.5)

Is this a battle of teams looking to challenge the Bills in the AFC East?  It sure looks that way. The Patriots fell back to 7-9 after Tom Brady left, but now have two QBs in the fold that could make some noise in 2020: Cam Newton and Mac Jones.

Miami was a surprise team last season, going 10-6 but still missing out on the playoffs: you needed 11 wins to get into the AFC Playoffs in 2020. Which of these two teams is going to start 2021 with a victory?

Green Bay Packers (-2.5) at New Orleans Saints

Aaron Rodgers is back in the fold in Green Bay, after some long days for Packers’ fans this summer. The reigning league MVP will most certainly show up and play well, and Green Bay could walk the NFC North.

It looks like “Famous” Jameis Winston is going to get the call under center for the Saints, to replace Drew Brees. That might be a tough task, but Winston is talented and has looked good in the preseason. 

Denver Broncos (-1.5) at New York Giants

It is Teddy time in Denver, as Teddy Bridgewater takes over the starting quarterback role from Drew Lock. That is good news for Broncos’ fans, who were tired of seeing the slow starts to the last couple seasons with other signal callers.

It is time for Daniel Jones to step up under center with the Giants, who see Saquan Barkley return from injury to lead the backfield. This line has been around a pick since it was released, with the Broncos a slight favorite now.

Chicago Bears at Los Angeles Rams (-7)

It is Andy Dalton that will start the new campaign as the QB of the Bears, and not first round pick Justin Fields. How long that stays this way remains to be seen. It might be more down to the tough circumstances of this Sunday Night Football encounter, against one of the best defenses in the NFL.


Speaking of Aaron Donald (who won his third DPOY award in four years in 2020) and the Rams’ defense, they will be bolstered by the arrival of Matthew Stafford at quarterback. Now, LA won’t have to do as much on defense, as the offense should put up more points. I love the Rams in this game, and will put them in any parlay.

Read more about this game here.

Monday, Sept. 13

Baltimore Ravens (-4) at Las Vegas Raiders

So here we are, the final game of Week 1, and it is another good one. The Baltimore Ravens’ offense sputtered at the end of 2020, after Lamar Jackson won the MVP in 2019. This is a good game to see if the Ravens can get the motor purring again.

Las Vegas will have a tough time limiting the Baltimore offense and will have to outscore them in this contest. I don’t know if that is something the Raiders can do.

Read more about this game here.

NFL Betting Lines Week by Week Index

Check out our NFL Betting Lines provided by proven experts. See their success rates and what lies ahead in the future.

Week 1 NFL Lines – NFL Week 2 Lines – NFL Week 3 Lines – NFL Week 4 Lines – Week 5 NFL Lines – Week 6 NFL LinesWeek 7 NFL LinesWeek 8 NFL LinesWeek 9 NFL LinesNFL Week 10 LinesWeek 11 NFL LinesWeek 12 NFL LinesWeek 13 NFL LinesWeek 14 NFL LinesNFL Week 15 LinesNFL Week 16 LinesWeek 17 NFL Lines NFL Playoffs LinesNFL Wild Card LinesNFL Divisional Round LinesNFL Conference Championship LinesSuper Bowl Lines

message icon background
Join Our Tribe

Get all the latest sports news, expert tips and reviews.

Accept Cookies

To improve your user experience, we use cookies on our website. By continuing to use the service, you accept the use of cookies and our privacy policy.

Additional Information
ACCEPT
DECLINE
responsible 18responsible 21responsible 21
HowToBet.com - Sports Betting & USA Online Gambling Guides

We are committed to sharing our expert betting knowledge so you can have a winning chance against the bookie, the house or even naming the winner of the next Dancing with the stars.

HowToBet.com is part of Raketech Group - licensed and operating in PA, NJ, IN, CO, WV, MI, TN, IL, VA. Address: 263 Shuman Blvd Ste. 145, Naperville, IL 60563, United States

Disclaimer: It is your responsibility to check gambling regulations in your jurisdiction. Howtobet.com does not accept responsibility for factual errors that may be evident. The site contains commercial content. This website is not responsible for third-party privacy policies.