Thursday Night Football Odds & Lines | How To Bet

Thursday Night Football Odds and Lines for Successful Betting

Thursday Night Football odds bring an exciting opportunity to enjoy NFL betting every single week. With 'hump day' behind you and only one day of the working week remaining, it's no wonder that betting on Thursday night football odds is a high point of the week for many. There’s a unique focus on the NFL’s weekly standalone contest and various elements that impact the Thursday Night Football betting lines and odds.

Here you’ll find all the information you need if you want to know how to bet on this weekly high point. We'll give you a Thursday night football preview, discuss the NFL Thursday night football betting trends, and basically do our very best to help you pick the Thursday night football winner. The best NFL odds for the TNF games will also be presented to you, so take a look through the opportunities available, help yourself and enjoy a great night of successful betting!

For more NFL content, make sure to check our NFL Picks page.

San Francisco 49ers (8-6) at Tennessee Titans (9-5)

Oh look, a National Football League primetime game during the week.

Isn’t that special!

Well, I guess maybe this week it might not be, as Week 15 of the NFL slate bleeds into Week 16. COVID-19 has wreaked havoc with rosters and the television schedule, and we had two Monday games, two Tuesday games (all Week 15), and now we get the best of them all, as Week 16 kicks off in Tennessee.

The Titans are reeling after an 8-2 start: they have lost three of four, and are still very much banged up heading into this encounter with the surging San Francisco 49ers. San Fran has won five of six, and blew out potential NFC playoff team Atlanta 31-13 on Sunday. The tone for that game was set in the opening minutes: the 49ers fumbled the opening kickoff, then stopped the Falcons cold on fourth and goal from the one.

There are four (really five if you count the Christmas 4:30 kickoff) primetime games this week, and all of them are very important to the playoff races in each conference. This game, and the Saturday night contest between the surging Colts and suddenly-struggling Cardinals, look to be the two best, and have many parallels: two teams back from the early season dead playing two of the early season NFL surprises.

One thing is for sure, though; the NFL has knocked it out of the park with its Thursday Night Football games all year: even when they have not looked like interesting matchups, they have worked out well for fans, and bettors, to make some money.

I would expect this game to be no different. If you are a fan of home dogs in primetime, you are going to have a chance to make some serious cash here.

Here is a look at the first game of Week 16.

NFL Week 16 Thursday Night Football 

  • Matchup: San Francisco 49ers (8-6) at Tennessee Titans (9-5)
  • Time: 8:20 p.m. EDT, 7:20 p.m. CDT, 6:20 p.m. MDT, 5:20 p.m. PDT        
  • TV Channel: NBC and fubo.TV
  • Last Week’s Scores: the 49ers routed the Falcons 31-13, while the Titans fell 19-13 to the Steelers, when a last minute drive was stopped at the 10 yard line.
  • Opening Moneyline Odds: 49ers (-175), Titans (+145)
  • Current Moneyline Odds: 49ers (-161), Titans (+160)
  • Opening Point Spread Lookahead Line: 49ers -3.5
  • Current Point Spread Lines: 49ers -3.5
  • Over/Under Total Opening Line: 44.5
  • Current Over/Under Total: 44.5

🤕 Injury Updates: San Fran is still missing some key players, especially on defense, but just keeps winning with what they have.

Julio Jones did not play due to a hamstring injury, and the short week might make it tough to get back for Thursday.

Remember, with COVID-19, the status of players can change quickly, so make sure you check the NFL injury report here before the game. 

  • Head To Head: these teams usually play every four years, so there is not much of anything to go on here. San Fran won 25-23 in 2017 with drastically different teams
  • What To Watch For:  these two teams are seemingly going in opposite directions, at a pivotal time of the year. Tennessee has lost three of four, but will be a different team come playoff time once the Titans get everyone back in the fold.

San Francisco has won five of six, and has looked dominant at times doing so. This should be another very good game on Thursday Night Football, and it could come down to the wire. This is a huge game for the playoff hopes of both teams: with the Colts coming on like a freight train in the AFC South, Tennessee really HAS to win here. San Fran needs this as well, because nine wins is almost certainly getting you in the playoffs: but the NFC West is all of a sudden back in play as well.

Prediction: everything here points to a 49ers’ road win, so of course I am going to look the other way and pick the Titans for some reason. Well, that reason is that they are at home, on Thursday night, and I feel like this is a little bit of a last stand. Tennessee 24-21

Best Prop Bets For Thursday Night Football:

  • Titans race to 20 points (+170)
  • Titans over 16.5 points (-120)

Thursday Night Football Odds for This Week

Thursday Night Football predictions are so important because every week of the NFL season starts with a matchup. Here, we will look at the Thursday Night Football betting odds and lines for this week’s matchup and what impacts them. Our aim is to help you identify the Thursday night football best bets and pick the Thursday night football winner so that you can convert your prediction into cash.

There are many betting operators to choose from, depending on your location in the US. DraftKings, PointsBet, FanDuel, William Hill, and BetMGM are among the US SportsBooks offering TNF lines. As a primetime game, many will also offer game and player props, which could have Thursday night football odds boosts and special offers.

Thursday Night Football Betting Tips

The Thursday Night Football games are not easy to handicap, and the Thursday night football odds reflect that. Usually, both teams are on short rest with a condensed practice week and less recovery time for injuries.

If a team is coming off a bye week or has extra days off, that can be a big boost to winning a TNF bet. You also want to find the healthiest team so get the most up-to-date injury reports before making a bet.

There’s not a lot of time for narratives to develop for a Thursday game. The home team has an advantage with more practice time since they don’t have to travel. With less practice time, the better coaching staff also has more of an impact on this game. Again, the Thursday night football odds will take those factors into consideration.

Thursday Night Football Odds: The Markets

Thursday night football odds are available for all of your favorite NFL betting markets. The main ones to look out for are as follows:

Thursday Night Football Moneyline

The Thursday night football moneyline market requires you to predict which team will win the game. Nothing more and nothing less. Bet on the team you expect to win and if they succeed then your bet will do likewise at the Thursday night football odds offered. This is a simple market but it doesn't tend to offer the best Thursday night football odds about the favorites, so it isn't as popular as the Thursday night football spread.

Thursday Night Football Spread

Also known as the Thursday night football point spread, the Thursday night football spread market requires you to predict which team will win and by how much. Although this is a bit more of a challenge than that posed by the moneyline, the Thursday night football spread will usually offer you better Thursday night football odds for a winning bet. That makes the Thursday night football point spread particularly attractive to bettors everywhere.

Thursday Night Football Prop Bets

You won't need to predict the winner of the game at all when you make Thursday night football prop bets, which are also known as TNF prop bets. Instead, you'll be betting on an outcome that will take place within the game. Example prop bets Thursday night football fans can make include whether or not a certain player will make a touchdown and which team will score first. The Thursday night football odds available for Thursday night football prop bets tend to be even more generous than for the Thursday night football spread, but Thursday night football prop bets are also more difficult to win with. That said, the prop bets Thursday night football offers are as exciting as they get.

Over/Under Thursday Night Football

Bet on the over/under Thursday night football and you only need to predict whether the total number of points scored will be over or under a figure quoted by the online sportsbooks. This makes over/under Thursday night football bets very attractive, especially to those who can't quite decide who will win, but feel more confident about how many points will be scored. The Thursday night football odds for this market will tend to be modest, but balanced.

There are other markets that you can look at, each offering their own Thursday night football odds. However, these are the best bets for Thursday night football and the ones you would do well to focus on. If you think that you will be able to predict the Thursday night football winner, the Thursday night football spread or moneyline will be most suitable. If you'd rather avoid having to make that prediction, focus on the Thursday night football prop bets or over/under Thursday night football opportunities. TNF prop bets are probably the ones to look at if you want the biggest Thursday night football odds.

Thursday Night Football Schedule

The NFL tries to make sure no team is forced to play more than one Thursday Night Football game per season. The league wants to ensure teams don’t have to endure the short week of practice required more than once.

The NFL also tries to make sure the Thursday Night Football game is a marquee matchup, worthy of being the lone game on that day and broadcast in primetime.

Here’s a look at this season’s Thursday Night Football schedule:

Sept. 9Dallas Cowboys at Tampa Bay Buccaneers8:20 p.m. ESTon FOX/NFL
Sept. 16New York Giants at Washington Football Team8:20 p.m. ESTon FOX/NFL
Sept. 23Carolina Panthers at Houston Texans8:20 p.m. ESTon FOX/NFL
Sept. 30Jacksonville Jaguars at Cincinnati Bengals8:20 p.m. ESTon FOX/NFL
Oct. 7Los Angeles Rams at Seattle Seahawks8:20 p.m. ESTon FOX/NFL
Oct. 14Tampa Bay Buccaneers at Philadelphia Eagles8:20 p.m. ESTon FOX/NFL
Oct. 21Denver Broncos at Cleveland Browns8:20 p.m. ESTon FOX/NFL
Oct. 28Green Bay Packers at Arizona Cardinals8:20 p.m. ESTon FOX/NFL
Nov. 4New York Jets at Indianapolis Colts8:20 p.m. ESTon FOX/NFL
Nov. 11Baltimore Ravens at Miami Dolphins8:20 p.m. ESTon FOX/NFL
Nov. 18New England Patriots at Atlanta Falcons8:20 p.m. ESTon FOX/NFL
Nov. 25Buffalo Bills at New Orleans Saints8:20 p.m. ESTon FOX/NFL
Dec. 2Dallas Cowboys at New Orleans Saints8:20 p.m. ESTon FOX/NFL
Dec. 9Pittsburgh Steelers at Minnesota Vikings8:20 p.m. ESTon FOX/NFL
Dec. 16Kansas City Chiefs at Los Angeles Chargers8:20 p.m. ESTon FOX/NFL
Dec. 23San Francisco 49ers at Tennessee Titans8:20 p.m. ESTon FOX/NFL
Thursday Night Football Schedule

Best NFL Betting Sites

If you want the best Thursday night football odds, and the widest range of TNF prop bets, you'll want to bet at the best NFL betting sites. Visit our online sportsbooks page for details of the best sportsbooks around, or take your pick from the selection below. And remember, you can get the best bets for Thursday night football from more than one site, so if you sign up with two or more sportsbooks you'll have a greater choice of best bets for Thursday night football.

How to Watch Thursday Night Football

Finding the best Thursday night football odds is one thing, but you'll also want to know how to watch Thursday Night Football games so that you can watch the action unfold in real-time. Thursday night football games are on NFL Network when the season starts. The games also get added to FOX and Amazon Prime starting in Week 5. The only exception is the Thanksgiving night game, which is on NBC. Whatever channel you tune into, there's nothing like watching your Thursday night football odds being landed

Thursday Night Football Odds and Lines FAQ

What Time Does Thursday Night Football Air?

All of the Thursday Night Football games start at 8:20 p.m. ET.

What channel airs Thursday night football?

The first four games are exclusively on NFL Network. The games from Weeks 5-16 will be simulcast on FOX, NFL Network, and Amazon Prime.

How can I find Thursday night football on TV?

For the first four weeks, you will need a cable/satellite package that includes NFL Network. After that, the games are on regular FOX and Amazon Prime as

How do I stream Thursday night football?

Thursday Night Football can be streamed through or the FOX Sports Go app. The games on Amazon Prime can be viewed through the Prime App. Games on NFL Network and FOX can also be streamed on multiple services like Roku, Twitch, PS4 and Xbox One.

How do I watch Thursday night football on Amazon Prime?

The Thursday Night Football games are available to all Amazon Prime customers and can be viewed on any device with the Prime App and a Prime subscription.

About Sean Miller
Sean Miller author profile

Sean has been covering sports for the Trenton Times and since 2013 and has been writing about sports betting since 2017. He was the beat writer for the Premier League for six years and for the TrentonThunder, the Double-A affiliate of the New York Yankees, now going on his seventh season. Sean also covers local sports (baseball, basketball, football, golf, ice hockey, volleyball, and wrestling) for the Times. He has a UEFA B license (so he knows a little bit about soccer) and is a big fan of the Red team in Manchester.

Was this article helpful?

10 People have found this article helpful. Your feedback helps us improve our work.

message icon background
Join Our Tribe

Get all the latest sports news, expert tips and reviews.

Accept Cookies

To improve your user experience, we use cookies on our website. By continuing to use the service, you accept the use of cookies and our privacy policy.

Additional Information
responsible 18responsible 21responsible 21 - Sports Betting & USA Online Gambling Guides

We are committed to sharing our expert betting knowledge so you can have a winning chance against the bookie, the house or even naming the winner of the next Dancing with the stars. is part of Raketech Group - licensed and operating in PA, NJ, IN, CO, WV, MI, TN, IL, VA. Address: 263 Shuman Blvd Ste. 145, Naperville, IL 60563, United States

Disclaimer: It is your responsibility to check gambling regulations in your jurisdiction. does not accept responsibility for factual errors that may be evident. The site contains commercial content. This website is not responsible for third-party privacy policies.