NFL Lines Week 6: Odds And Lines Comparisons At Major US Sportsbooks

• Football

So here we are, at Week 6 of the National Football League season.

We had our first NFL London game at the glorious Tottenham Stadium, and despite the teams playing in that game (Atlanta and the New York Jets), it was an entertaining contest. This week, the two Florida teams will face off in London, in a game that might not be as entertaining.

But where are we right now, as in, what is the state of the NFL as teams start getting their bye weeks? Well, there are some very good teams at the top of the NFC. Five teams are already either 4-1 or 5-0, with the surprising Arizona Cardinals (well, not surprising to me if you have been reading or listening to How to Bet) leading the way as the last unbeaten team. But Dallas, Green Bay, Los Angeles, and Tampa Bay are all 4-1 heading into the new week of action. There are also three more 3-2 teams: the Bears, Panthers, and Saints. The race for the NFC Wild Card spots is shaping up to be a good one.

What about the AFC? Right now, it sure looks like the Buffalo Bills (4-1) and Los Angeles Chargers (4-1) are the class, with the Ravens in with a shout as well. But how about the two-time defending AFC champion Kansas City Chiefs? Every week that goes by gives more credence to the Super Bowl loser hangover curse, but there is still a lot of time to turn it around for the Chiefs. Will they?

I am personally excited to get a chance to be at the Thursday Night game this week, as Tom Terrific and the Tampa Bay Bucs head into Philly to take on the Eagles.

There are some very intriguing games all over the schedule, and in all of the windows. Tune in to the How to Bet podcast as we will break down the Top 5 NFL Plays of the Week, which will include all the primetime games plus two big ones: the LA Chargers at the Baltimore Ravens, and the Cardinals at Cleveland. 

Here is a look at all the odds and games for NFL Week 6.


Here are your updated NFL Week 6 odds, all in one place. Check back daily to see updates.

NFL Week 6 Opening (Lookahead) Spreads

GameLookahead lineCurrent spreadMoneyline
Buccaneers at EaglesBuccaneers -7Buccaneers -6.5Buccaneers -310, Eagles +250
Dolphins at JaguarsDolphins -3Dolphins -3Dolphins -162, Jaguars +136
Chargers at RavensRavens -3Ravens -3.5Ravens -172, Chargers +144
Vikings at PanthersPanthers -1Panthers -1.5Panthers -124, Vikings +104
Packers at BearsPackers -4.5Packers -4.5Packers -230, Bears +190
Texans at ColtsColts -10Colts -10Colts -500, Texans +385
Bengals at LionsBengals -3.5Bengals -3.5Bengals -190, Lions +160
Rams at GiantsRams -6.5Rams -10.5Rams -490, Giants +380
Chiefs at WashingtonChiefs -6.5Chiefs -6.5Chiefs -290, Washington +230
Cardinals at BrownsBrowns -3Browns -3Browns -158, Cardinals +134
Raiders at BroncosBroncos -2.5Broncos -3Broncos -146, Raiders +124
Cowboys at PatriotsCowboys -1.5Cowboys -3.5Cowboys -196, Patriots +164
Seahawks at SteelersSeahawks -2.5Steelers -3.5Steelers -200, Seahawks +168
Bills at TitansBills -3.5Bills -3.5Bills -200, Titans +170
NFL Week 6 Opening (LOOKAHEAD) Spreads
  • Tampa Bay Buccaneers (-7) at Philadelphia Eagles (+7)
  • Miami Dolphins (-3) at Jacksonville Jaguars (+3), in London 
  • Los Angeles Chargers (+3) at Baltimore Ravens (-3)
  • Minnesota Vikings (+1) at Carolina Panthers (-1)
  • Green Bay Packers (-4.5) at Chicago Bears (+4.5)
  • Cincinnati Bengals (-3.5) at Detroit Lions (+3.5)
  • Los Angeles Rams (-6.5) at New York Giants (+6.5)
  • Kansas City Chiefs (-6.5) at Washington Football Team (+6.5)
  • Arizona Cardinals (+3) at Cleveland Browns (-3)
  • Las Vegas Raiders (+2.5) at Denver Broncos (-2.5)
  • Dallas Cowboys (-1.5) at New England Patriots (+1.5)
  • Seattle Seahawks (-2.5) at Pittsburgh Steelers (+2.5)
  • Buffalo Bills (-3.5) at Tennessee Titans (+3.5)


Tampa Bay Buccaneers (4-1) at Philadelphia Eagles (2-3), 8:20 p.m. EDT (NFL and fubo.TV)

Obviously, the Bucs come into this game as one of the best teams in the NFC and the NFL. Maybe not as obvious is the improvement of the Eagles, who have played well even in losses and are 2-3 after five weeks. Not bad for a team that some thought would struggle to win four or five games.

This is a much bigger test for Philly, though: Tom Brady and the Bucs offense that has shredded defenses at times in 2021.

Read more about this game here in our Thursday Night Football Best Bets guide.

Miami Dolphins (1-4) vs. Jacksonville Jaguars (0-5), 9:30 a.m. EDT (CBS and fubo.TV)

Let me ask you a question: is there any way that the Jaguars pull off a reverse Ted Lasso here and bring Jurgen Klopp or Pep Guardiola back to America to take over this absolute dumpster fire of a team? Shahid Khan does own Fulham FC, you know.

If the weather in London is rainy (when isn’t it?), and the field is a bit of a mess, this could be a disaster of a game. Can Trevor Lawrence get his first win? Will the Dolphins start winning? Remember, they won 10 games in 2020.

Green Bay Packers (4-1) at Chicago Bears (3-2), 1p.m. EDT (FOX and fubo.TV)

This has turned into a very big contest in the NFC North. Both teams come in with winning records, although it is the surprising Bears that have a chance here to throw down the gauntlet in the division with a win.

Justin Fields hyperextended his knee in the 20-9 win over the Raiders, but kept playing. If Chicago is going to win this, it will be on the back of its defense, anyway: that unit has been very impressive in the three wins. It will have to be again, with Aaron Rodgers in town. Just hope it does not come down to a field goal, right Packers' fans?  

Cincinnati Bengals (3-2) at Detroit Lions (0-5), 1p.m. EDT (FOX and fubo.TV)

Is there a better 0-5 team in the NFL than the Detroit Lions? Well, no, because Jacksonville stinks. But the Lions continue to play well in losses and have lost two of the last three games by a last-second field goal. They are close to turning the corner.

Will it be this week against the banged-up Bengals? Joe Burrow is questionable, Milke Thomas is as well, and this could be a tough spot for Cincinnati. Tough to bet this one without knowing if Burrow will play.

Just hope this doesn’t come down to a field goal, right Bengals fans?

Houston Texans (1-4) at Indianapolis Colts (1-4) , 1p.m. EDT (CBS and fubo.TV)

I have been interested to see this Houston team play this year. The Texans were supposed to be awful. Their record is not good, but they have played hard. Davis Mills might have figured it out as well: he had 312 yards and three TDs in the tight loss to New England.

Indianapolis is tough to figure out as well. They are another team that has not played as bad as their record suggests.

LA Rams (4-1) at New York Giants (1-4), 1p.m. EDT (FOX and fubo.TV)

This one is going to be a quick preview. The Giants might be without QB Daniel Jones, RB Saquon Barkley, and a host of other players.

The Rams are very good, and will come into this game looking to post a big number on offense to keep pace with the rest of the NFC top tier teams. Get this before the line moves up toward two TDs.

Kansas City Chiefs (2-3) at Washington Football Team (2-3), 1p.m. EDT (CBS and fubo.TV)

Is there a more frustrating team to bet right now than the two-time defending AFC champions? The offense has been good, but Patrick Mahomes might be getting tired carrying this team and the defense, which has been ATROCIOUS. I put that in caps because I can’t yell it loudly enough, although I will on the How to Bet podcast. The Chiefs’ defense stinks.

What about the Washington defense? It was supposed to be good but gets shredded each time out on the field as well. I would have to go with Kansas City here, but do you trust this team at all of you have been betting on them? They are also terrible against the spread since the start of 2020.

Minnesota Vikings (2-3) at Carolina Panthers (3-2), 1p.m. EDT (FOX and fubo.TV)

Here we go again with two more teams no one can figure out: both the Vikings and Panthers had chances to make statements last week, but did not. At least Minnesota won: Carolina lost to the Eagles, letting the visitors go right down the field against a supposedly tough defense to win the game.

I just don’t see how you can trust the Vikings enough to bet on them, and I think the line, which will be close to a pick, shows that the public and the books have no read on either team. If I had to pick, I would take Minnesota.

LA Chargers (4-1) at Baltimore Ravens (4-1) , 1p.m. EDT (CBS and fubo.TV)

This might be the best game of the weekend. The Chargers are for real, and have to be the favorites to win the AFC West. LA scored 26 points in the fourth quarter to rally and beat the Cleveland Browns in what was the game of the year so far, with Justin Herbert throwing for 398 and four scores. They remind me of the 2018 Chiefs and the 2020 Bills: just on the cusp of greatness.


Arizona Cardinals (5-0) at Cleveland Browns (3-2), 4:05 p.m. EDT (FOX and fubo.TV)

If the last game is not the game of the day, this one will be. Cleveland is about “this close” to being 5-0 on the campaign but is 3-2. Baker Mayfield looked much better last week, throwing for 302 yards in the loss to the Chargers.

Arizona has shown it can light up the scoreboard under Kyler Murray, and now the public knows the Cards can win behind their defense. Isaiah Simmons’ goal-line stop on fourth down showed just how much this defense has improved. This should be a fantastic contest.

Las Vegas Raiders (3-2) at Denver Broncos (3-2), 4:25 p.m. EDT (CBS and fubo.TV)

Two teams that were the final AFC unbeatens come into this contest on two-game losing streaks, and maybe more towards where they really are.

Las Vegas and Denver are both 3-2, but both are in the AFC West discussion with a victory here. Both teams have struggled the last two weeks offensively, so it might be worth it to look at the team with the better defense: Denver. But this would be a no play for me in this spot.

Dallas Cowboys (4-1) at New England Patriots (2-3), 4:25 pm EDT (CBS and fubo.TV)

To me, this looks like a mismatch, which makes this line that much tougher to read. Maybe people do not trust Dallas yet, but the Cowboys are back to their best, and are putting up gaudy offensive numbers. If the defense can come around even just a little bit…

The Patriots are in every game, but do not put up big offensive numbers. They also let teams hang around in games. If this line stays where it is, you have to jump on the Cowboys.

Seattle Seahawks (2-3) at Pittsburgh Steelers (2-3), 8:20 p.m. EDT (NBC and  fubo.TV)

While this might not be the most glamorous game of the weekend, it might be an elimination game of sorts for both teams involved.

One of these teams is going to fall to 2-4, and even with the expanded playoffs and the 17-game schedule, that might be too deep of a hole to climb out of over the next two months. I don’t actually think either team is that good, but the Steelers probably have the better chance to make the playoffs, especially with Russell Wilson out for at least a month for Seattle.

Read more about this game in our Sunday Night Football Best Bets guide.

Buffalo Bills (4-1) at Tennessee Titans (3-2), 8:15 p.m. EDT (ESPN and fubo.TV)

Both of these teams should be in the playoffs in January: well, the Bills will definitely be (if they stay healthy), and Tennessee should be, because its division stinks. 

This is a test game for both. Buffalo went on the road and crushed the Chiefs to avenge their AFC Championship Game loss, and now has to come back in primetime and keep the same intensity after that massive victory. For the Titans, this is a chance to beat the best team in the AFC, and throw down their own marker.

As an aside, how good have the primetime games been so far in 2021? Long may those continue.

Read more about this game in our Monday Night Football Best Bets guide.

NFL Betting Lines Week by Week Index

Check out our NFL Betting Lines provided by proven experts. See their success rates and what lies ahead in the future.

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