NFL Picks Week 1 | NFL Week 1 Predictions | How To Bet

NFL Picks Week 1 for a Winning Start at Betting

Check the Hottest NFL Week 1 Predictions by Our Expert Team

Autumn is coming… and so does the new season with our NFL Picks Week 1 to help you make a winning start at betting. This represents a huge opportunity to exploit some ill-judged odds by sportsbooks. Because, while there is tons of information and data on all of the teams, the beginning of any season means starting with a clean slate for many of them. This is their chance to show the nation and the world that they can be winners and no one should underestimate this renewed ambition. How To Bet experts are here to hunt down these golden nuggets and serve them on a silver plate for you with our hot NFL Week 1 predictions.

Doing your own research for every game is hard enough, and it’s way more so when the season hasn’t started yet. Because of that, follow our NFL Picks – the success rates of How To Bet’s expert team prove our worth time and time again. On this page you can also check the odds movement and see the complete schedule of the games with detailed previews.

You are forgiven if you’ve let the excitement of the starting season take you over after this long and painful wait. We are here with our cool-headed expert approach though to help you benefit from the best NFL bets Week 1 can offer. Check our picks and begin the season in style… and with some well-earned money.

So let the show begin!.

NFL Picks Week 1: Predictions in Detail

Ravens @ Raiders – NFL Week 1 Picks and Predictions

Week 1 concludes with the Ravens visiting Las Vegas for the first time ever. Raiders are 3-8 all-time against the two-time Super Bowl champions, losing the last two games against them.

Raiders continued their long-standing trend to sign former defensive stars who are well over the hill. This year they added DE Gerald McCoy, LB K. J. Wright, and CB Casey Hayward to a unit that allowed 389.1 YPG last season. So why should Raiders have a chance?

Simply because Ravens fell victim to a series of catastrophic injuries and are extremely thin at RB. First J. K. Dobbins tore an ACL, then Justice Hill tore an Achilles tendon and on Thursday Gus Edwards suffered what is believed to be a season-ending knee injury. That leaves them with Ty`Son Williams who never had a carry in a regular-season game, veteran Le`Veon Bell who just signed with the team, and Davonte Freeman who was basically brought off the street. On top of that CB Marcus Peters also tore an ACL during Thursday’s practice and is out for the season as well.

Most NFL expert picks in Week 1 featured Ravens covering up the four-point spread. However, Thursday’s practice turned everything on its head. Add in the fact that the Raiders have won their last three Monday night home games and you should not feel comfortable betting against them.

NFL Week 1 Prediction: Under 50.5 (-110)

49ers @ Lions – NFL Week 1 Picks and Predictions

49ers were the most injury-struck team in 2020 with 161.1 adjusted games lost which is 22% more than the second team in the list. Now SF is healthy. On offense TE George Kittle is back, they have a new center (Alex Mack) and a promising young RB Trey Sermon to complement Raheem Mostert. Niners also traded up in the draft to select QB Trey Lance. However, the dual QB system head coach Kyle Shanahan wants to implement will have to wait a bit as Lance suffered a finger fracture in a preseason game against the Raiders.

On defense, Niners welcome back DE Nick Bosa and LB Dee Ford although the latter will be eased back and will have a limited number of snaps. The team is so stoked on defensive life that they chose to re-sign DE Jordan Willis even after his six-game suspension.

Lions start the season with a new HC (Dan Campbell), a new GM (Brad Holmes) but most importantly – a new starting QB. Detroit traded veteran Matthew Stafford to the Rams in exchange for Jared Goff who will have to prove that he’s more than a puppet of coach Sean McVay and can lead an NFL offense.

Even with the new additions, the Lions are still the same talent-depraved team that won 14 games in the last three seasons combined, hasn’t made it to the postseason since 2016, and hasn’t won a playoff game in 30 years. The line opened at 49ers -6.5 and climbed by a point during the last two weeks. Still, even playing in a different time zone SF should be able to win easily. BTW, the Niners have won 10 of the last 11 meetings with the Lions. This is one of the best NFL bets in Week 1.

NFL Week 1 Prediction: 49ers -7.5 (-105)

Cardinals @ Titans – NFL Week 1 Picks and Predictions

Most NFL expert picks for Week 1 shy away from this game. But the Titans will be a very interesting team in 2021. They were loaded on offense even before trading for WR Julio Jones who gives them another deep threat alongside A. J. Brown. RT situation looks a little murky and HC Mike Vrabel refuses to name a starter. It will be either former second-round draft pick Ty Sambrailo and Kendall Lamm who interestingly caught a TD pass as a member of the Cleveland Browns against the Titans last season. But whoever is chosen should make no difference to the dominant running game.

On defense, the Titans made a surprising choice to promote Shane Bowen to defensive coordinator. He was the de facto coordinator in 2020 and his unit ranked 30th in sacks and 29th in yards allowed. Don’t be surprised if Titans’ games this year turn into a shootout.

Cardinals’ Kliff Kingsbury is the odds-on favorite to be the first fired head coach and his seat couldn’t be hotter. Arizona lost key veterans (WR Larry Fitzgerald, CB Patrick Peterson, RB Kenyan Drake) while doing little to replace them. Moreover, free agent signing CB Malcolm Butler announced his surprise retirement on August 31st which led to some speculations about the team culture.

QB Kyle Murray is always a dual-threat and WR DeAndre Hopkins is still in his prime. However, veteran A. J. Green had his worst season in 2020 and looks like a bad fit at WR2. On defense DE J.J. Watt and LB Chandler Jones look well past their best years and the Cardinals may need to score 30 to win. And it still shouldn’t be enough on Sunday.

NFL Week 1 Prediction: Titans -3 (-105)

Dolphins @ Patriots – NFL Week 1 Picks and Predictions

After finishing with a losing record for the first time in two decades, the Patriots will try to change fortunes with a rookie QB. Last year starter Cam Newton was released after an uninspiring preseason and a lack of COVID vaccination. Enter Mac Jones, the #15 pick in this year’s draft. Judging by the 53-man roster, the Patriots will try to turn into a run-first team. They reacquired OT Trent Brown from the Raiders and traded for OT Yassir Durant from the Chiefs.

On defense, CB Stephon Gilmore will miss at least the first six weeks of the season and CB Jason McCourty signed with the Dolphins but apart from that the unit is largely intact.

Dolphins were a win away from going to the postseason in 2020 and have won 15 of their last 25 games. Yet they actively tried to acquire Texans QB Deshaun Watson before he ran into legal troubles and it’s not exactly a vote of confidence on incumbent starter Tua Tagovailoa. The team revamped defensively putting an emphasis on pass defense. Whether 

The game will be a rare instance with two teams starting a former Alabama QB. The perennial NCAA champions are anything but a QB factory with most of their products having short and unremarkable NFL careers. Running game consumes time and teams won’t have that many drives. Plus Dolphins LT Austin Jackson is doubtful for Sunday.

NFL Week 1 Prediction: Under 43.5 (-105)

Bears @ Rams – NFL Week 1 Picks and Predictions

The first Sunday Night Football game features Super Bowl hopefuls LA Rams against the highly dysfunctional Chicago bears. It will be the first regular-season game with fans at SoFi Stadium – home of Super Bowl LVI next February, and it will be the first test whether the home crowd will be a factor or not. But still, this game is a must among NFL picks for Week 1.

During the offseason Rams once again mortgaged their future by sending a couple of the first-round drafts picks to Detroit in exchange for QB Matthew Stafford. While the former #1 pick is undoubtedly an upgrade over Jared Goff he’s already 33 years old and with just seasons left of his current contract. On offense Rams also had to trade for New England RB Sony Michel as Cam Akers will be on the IR for at least six more weeks. They also signed WR DeSean Jackson as a deep threat but with just 23 passes caught during the last two seasons combined it’s unknown what his impact will be.

Bears are in a strange QB situation. They drafted Ohio State’s Justin Fields at #11 but he will have to wait a bit as a veteran free agent signing Andy Dalton (6-19-1 in primetime games) has a clause in his contract that mandates he’s a Week 1 starter. On top of that Bears’ O-Line is very suspect as they signed off the street 39-year old Jason Peters as LT and brought disappointing Germain Ifedi from the Seahawks to start at RT. And their first assignment is stopping the reigning Defensive Player of the Year Aaron Donald. Good luck with that!

NFL Week 1 Prediction: Rams -7.5 (-104)

NFL Picks Week 1 in Brief

  • Eagles @ Falcons (-3.5): Two teams with rookie head coaches and not a lot of talent on the roster. Well at least the Falcons still have QB Matt Ryan
  • Steelers @ Bills under 48.5: Steelers DE T.J. Watt ended his holdout and is expected to play. Unless red zone offenses are in midseason form this will not turn into a slugfest.
  • Jets (+4) @ Panthers: New Panthers QB Sam Darnold has his first chance for a shot at his former team. Or maybe it will prove the Jets were right trading him away?
  • Vikings (-3) @ Bengals: Vikings have improved their defense but what about the anti-vaxxer Kirk Cousins? And will Bengals WR Ja’Marr Chase be able to identify the color of the ball?
  • Jaguars (-3) @ Texans: Tyrod Taylor is the likely starting QB for the Texans who have won six straight against Jacksonville. This is an excellent opportunity for the Jaguars to stop the streak.
  • Seahawks @ Colts (+3): Seahawks tried to trade QB Russell Wilson away in the offseason. And they still expect him to be the leader of the team…
  • Chargers @ WFT over 44.5: WFT signed Ryan Fitzpatrick to be their QB. Usually he’s Fitzmagic during the first month before turning into a pumpkin. And Chargers QB Justin Herbert is simply good.
  • Browns @ Chiefs over 54.5: In a 90 degree heat both defenses may be gassed even before halftime.
  • Packers (-4) @ Saints: It’s hard to bet against the Packers even without LT David Bakhtiari. Especially when the game is on a neutral field in Jacksonville.
  • Broncos (-3) @ Giants: Giants have RB Saquon Barkley and WR Kenny Golladay back and healthy. But their O-Line is still bad.

Thursday Night Football: Cowboys @ Buccaneers - Top NFL Week 1 Picks and Predictions

It’s time to return to normality in the NFL at least regarding fans in the stadiums. Tampa Bay Buccaneers will get the chance to parade the Lombardi Trophy in front of their supporters and then slaughter the hapless Dallas Cowboys. This is what conventional wisdom is saying.

And while the Cowboys are one of only two teams to beat the defending Super Bowl champions in the NFL Kickoff Game away from home (24:17 against NY Giants in 2008) a loss to the Buccaneers looks like the most obvious NFL picks for Week 1.

It’s not like Dallas has no options on offense. After two straight 1000 receiving yards seasons Amari Cooper is still among the top echelon of wide receivers. CeeDee Lamb was close to joining Cooper in “1000 yards club” in 2020 and Ezekiel Elliott is due for a rebound season after nearly missing rushing for 1000 yards last season. However, QB Dak Prescott is coming off major foot surgery and was shut down from throwing during the training camp with a lat strain. This type of injury usually takes a couple of months to fully heal so despite the declarations from OC Kellen Moore whether Prescott is fully healthy is yet to be seen.

The biggest concern for the Cowboys is the trenches. On OL Tyron Smith and La’el Collins are the only respectable players and the Cowboys can’t afford to lose any of them. The DL is suspect at best and with DT Neville Gallimore out for September, the Cowboys will have to start two rookies on Thursday. On top of that their secondary is projected to be one of the worst in the NFL with Trevon Diggs, Anthony Brown and Jourdan Lewis expected to start at CB. Couple this with the arrival of the new DC Dan Quinn who will need time to install the new Cover-3 scheme and the Cowboys should have a long and forgetful Thursday night in Tampa Bay.

After all, the Buccaneers are the first Super Bowl champion to return all 22 starters. That includes Tom Brady who led the team to an eight-game winning streak to finish the 2020 season averaging 33 points per game and hitting the 30-point mark in all four playoff contests. And the Buccaneers added Giovani Bernard to complement Ronald Jones II and Leonard Fournette at RB.

The line opened at -6 but with some heavy betting on Buccaneers climbed to -7.5. Still, with the questions over Cowboys’ defense, even this may not be a challenge for Brady & Co and looks like one of the easiest NFL predictions for Week 1.

  • NFL Week 1 Prediction: Tampa Bay -7.5 (-111)

NFL Expert Picks Week 1: Why You Should Choose Them 

Before we reveal why you should go for NFL Expert Picks Week 1 instead of putting in long hours for your own ones, let’s answer the most basic question: what are NFL expert picks? They are selected betting predictions by individuals with a particularly high level of NFL knowledge and experience. The name itself hints that these picks are provided for the first week of the league season. These expert predictions will give you detailed suggestions on how to bet on those games that give you the highest winning chance for a wager.

While many bettors still lean towards making their own NFL Week 1 predictions, more and more people count on expert picks. A lot of people consider them to be the art form of NFL betting. Here are the main reasons to choose NFL Picks Week 1 provided by specialists:

  • They save you precious time – As we already mentioned, making just one well-researched pick requires putting in at least 5-6 hours. So coming up with justified NFL Week 1 predictions will consume the bulk of your precious time. Leave the hard work to the experts and live your life fully instead of staying glued to the screen, analysing tons of data and news reports. Then just collect your winnings and live some more.
  • They are counting on access to hardly accessible sources – How To Bet’s NFL Picks Week 1 are based on information sources which are not accessible for everyone. For instance, advanced statistical data that is pretty difficult to analyse as well. And you shouldn’t forget another important thing: these top sources are pretty expensive.
  • They are based on highly sophisticated betting models – The expert team behind our NFL Expert Picks Week 1 uses their own betting models and algorithms. They have been developed over many years, some for even more than a decade. As a result, on this page you will discover the very best NFL bets Week 1 can offer.
  • They follow the latest news reports 24/7 for an instant reaction – Not many people can afford to follow non-stop the latest league and team news from all types of high authority sources so that they are able to react and change their bet accordingly. Our experts can and do it though. They take into account all the important team news when making their NFL Week 1 predictions.
  • They are completely unbiased – Our NFL Picks Week 1 are provided by fully professional experts. All of them have a hunch for the game but will always look to support it with statistical and empirical evidence. How To Bet’s team doesn’t pick based on emotion or team loyalty – the predictions are always made completely rationally. 

NFL Picks Week 1: Explaining The Main Betting Types

Whether you use expert picks or your own, there is a big variety of betting markets when you come to wager on the chosen NFL Week 1 predictions. The three most popular among football betting aficionados are:

  • Moneyline
  • Point Spread
  • Over/Under

Due to their huge popularity, you will find these three markets at every accomplished online sportsbook. We will take a quick look at each one here. This way you will understand how they work before you begin exploring the best NFL bets Week 1 can offer.

NFL Week 1 Picks against the Spread

NFL Week 1 Picks against the Spread
NFL Week 1 Picks Against the Spread

The reason why people look for NFL Week 1 picks against the spread is that the odds for the two teams in an NFL game can be quite different. By trying to even them up, all sportsbooks offer point spread markets that impose an artificial handicap on the favorite team. The spreads give the underdog team an equal and opposing advantage, and consequently, the odds available tend to be much more balanced. As a result, the NFL Week 1 picks against the spread are in such demand. Consider this example:

TeamSpreadOdds
San Francisco 49ers-9.5-115
Detroit Lions+9.5-105
NFL Week 1 Picks Against the spread example

In this example for NFL Week 1 picks against the spread, you see San Francisco is given a handicap of -9.5 points, while Detroit has an advantage of +9.5 points. If you put a bet on San Francisco, the 49ers will need to win by 10 points or more for you to succeed. Bet on Detroit and that wager will only lose if the Lions lose by 10 points or more. With these conditions in place, the sportsbook is able to offer attractive odds for both teams.

You can bet that when you are using expert predictions, you will be given NFL Week 1 picks against the spread. Just wager on the named team in the point spread market and if the expert pick is correct, you’ll have your winning bet served on a plate.

Straight Up NFL Picks Week 1

The straight-up or moneyline betting market is perhaps the simplest to understand. Here you will be offered odds about both of the teams involved in a particular NFL game and your only job is to bet on the team that you think will win. If your prediction is correct, your bet is a winning one and it will be settled at the odds you took. In short, when you are seeing our straight-up NFL Picks Week 1, you should be able to bet on them easily. Take a look at the following example:

TeamOdds
Green Bay Packers-200
New Orleans Saints+170
Straight Up NFL Picks Week 1

So if in your NFL Week 1 predictions straight up you fancy Green Bay to win the NFL game against New Orleans, you could bet on the Packers at odds of -200. A stake of $200 would therefore give you a profit of $100 if they succeed. On the other hand, if you bet $100 on New Orleans and they win the game, your profit would be $170. This is as straightforward an example as you would find, so now you should be ready to take advantage of our straight-up NFL picks Week 1 picks.

NFL Picks Week 1 for Over/Under

The over/under betting is the third main betting market for NFL Picks Week 1. Here you don't wager on the winner of the NFL game. Your only job is to predict whether the total number of points scored in the game by both teams combined will be Over or Under a total figure quoted by the sportsbook. Unsurprisingly, this is the reason why this is also known as the Totals market. Have a look at the following example to understand the concept better:

Sportsbook TotalOdds
Over 52.5-110
Under 52.5-110
NFL Picks Week 1 for Over/Under

The over/under betting is just as simple as moneyline betting, especially if you have NFL expert picks Week 1 to help guide you. In this type of wagering all you have to do is decide whether you think there will be over or under 52.5 points scored in the game by both teams combined. If you go for Over, there would need to be 53 points or more for your wager to succeed. Go for Under and there would need to be 52 points or fewer for your bet to win. Take a look at our NFL Week 1 predictions, find the best over/under bets available, and put a wager.

NFL Picks & Predictions Week by Week Index

Check out the success rate of the NFL predictions provided by our experts and see what lies ahead in the future.

NFL Picks Week 1NFL Picks Week 2NFL Week 3 PicksNFL Week 4 Picks Week 5 NFL Picks – Week 6 NFL Picks – Week 7 NFL Picks – Week 8 NFL Picks – Week 9 NFL Picks – NFL Week 10 Picks – Week 11 NFL Picks – Week 12 NFL Picks – Week 13 NFL Picks – Week 14 NFL Picks – NFL Week 15 Picks – NFL Week 16 Picks – Week 17 NFL Picks – NFL Playoffs Picks & Predictions – NFL Wild Card Predictions & Picks – NFL Divisional Round Predictions & Picks – NFL Conference Championship Predictions & Picks – Super Bowl Predictions & Picks

NFL Picks Week 1 FAQ

What expert NFL Picks are?
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These are the expert’s betting choices for a NFL game and are based on hours and hours of research. You can either choose to follow these predictions or trust your own judgement.

Where can I find expert picks Week 1 NFL?
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There are many places where you can find expert picks Week 1 NFL. Not all experts are equal though, and most will charge you money to receive their picks. The NFL Picks Week 1 here at How To Bet are provided by some of the best specialists we’ve found and, this is the icing on the cake, completely free of charge.

How to make winning NFL Picks in week 1?
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In order to benefit from the best NFL bets Week 1 can offer, you need to do lots of research. You must check stats, injury lists, coach changes and anything that could affect the game. Most of all, you need to be able to analyse this information properly and also to read the game before all the action unfolds.

You can also follow expert NFL picks from Week 1 all the way to the Super Bowl. And it’s completely free of charge here at How To Bet!

Which NFL expert has the best record for NFL Picks?
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ESPN and CBS are regarded as the top of the pops for NFL picks among the big media outlets. But don’t hesitate to check How To Bet’s picks too. We have a great winning percentage that equals and many times even betters the success rates of the most popular experts..

Is there a guarantee that all NFL Picks Week 1 provided by experts are winners?
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Our NFL picks Week 1 are expert predictions based on solid data and analysis, but they are still only predictions. There is no guarantee that NFL picks from any source will win, and form upsets can occur at any point during the season. The only guarantee is that the expert picks have a much higher chance of winning because of the amount of work, knowledge, experience and advanced data access these specialists have. So always obey the golden rule of betting and never bet more than you can afford to lose in a worst-case scenario.

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