NFL Week 5 Betting Lines | Odds Comparisons At Legal US Sportsbooks
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NFL Week 5 Odds And Lines Comparisons At US Sportsbooks

It took just four weeks for the National Football League to deal with a COVID-19 outbreak, as one game was removed from the Week 4 slate, and another was pushed back a day. The league heads into Week 5 with a normal schedule, and the hope is that it will remain that way.


Also see:
 Best NFL Week 5 Offers From Us Sportsbooks 

There are just 15 games in Week 5 as the Detroit Lions and Green Bay Packers each have a bye. This still leaves plenty of great betting opportunities, and there are some interesting matchups on the schedule.

Here is a look at the Week 5 schedule with a quick betting overview for each game. 

NFL Week 5 Betting Lines

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Thursday, Oct. 8

Tampa Bay Buccaneers vs. Chicago Bears

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Click here: Tampa Bay Buccaneers (-5.5) at Chicago Bears Betting Preview

The Thursday Night Football game features the Chicago Bears hosting the Tampa Bay Buccaneers. Both teams come into this game with 3-1 records, but it is the Bucs that are favored on the road.

Tampa Bay has now won three straight games, and the offense is starting to click. Quarterback Tom Brady threw five touchdown passes in the Week 4 win over the Los Angeles Chargers.

Chicago has made a change at quarterback, but Nick Foles was not the answer in Week 4. The Bears scored just 11 points in a home loss despite another great performance from the defense.

Tampa Bay is the better team, and it wins this game by double-digits. 

Sunday, Oct. 11

Arizona Cardinals vs. New York Jets

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Click here for: Arizona Cardinals (-6.5) at New York Jets Betting Preview

The Arizona Cardinals have now lost two straight games in which they were favored. Arizona is a 6.5-point favorite over the New York Jets on Sunday.

Arizona got a poor performance from its defense in Week 4, as they gave up 31 points to the Carolina Panthers. The Cardinals have proven they can score, but they need to be solid on both sides of the ball.

New York is an absolute mess right now, and it’s unclear if Sam Darnold will be healthy enough to start at quarterback. The Jets suffered a 37-28 loss to the Denver Broncos on Thursday night in Week 4, and this team is searching for answers.

Arizona will get back on track and will cover the spread in this one.

Buffalo Bills vs. Tennessee Titans

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Click here for: Buffalo Bills (-6.5) at Tennessee Titans Betting Predictions

A pair of undefeated teams will square off in Tennessee on Sunday in what could be a potential playoff preview. Buffalo leads the AFC East with a 4-0 record, while the Tennessee Titans are tops in the AFC South at 3-0.

Buffalo has been getting terrific play from quarterback Josh Allen this season, and the defense remains strong. Newcomer Stefon Diggs had six catches for 115 yards in Week 4, and this offense should have another big day in this one.

Tennessee has played in several close games, but it continues to find ways to win. Running back Derrick Henry led the NFL in rushing a season ago, and he will be a huge key in this game.

There is too much uncertainty surrounding the Titans to pick them, as the Bills win this game by a touchdown. 

Carolina Panthers vs. Atlanta Falcons

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Click for: Carolina Panthers at Atlanta Falcons (-3.5) Betting Predictions

The 2-2 Carolina Panthers are 3.5-point underdogs on Sunday against the 0-4 Atlanta Falcons. Neither team feels like a playoff team at this point, but there is still time to turn things around. 

Carolina quarterback Teddy Bridgewater has been sharp for the Panthers, having thrown for 276 yards and two touchdowns in Week 4. The Panthers have been getting better defensive play of late, but that unit will be tested.

Atlanta suffered a 30-16 defeat at the hands of the Green Bay Packers on Monday night, and the defense continues to struggle. Quarterback Matt Ryan is capable of throwing for more than 300 yards, but Julio Jones will likely miss this game with injury.

The Falcons are too good to continue to lose, and they pick up their first win in this game. 

Cincinnati Bengals vs. Baltimore Ravens

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Click here for: Cincinnati Bengals at Baltimore Ravens (-13.5) Betting Predictions

The 1-2-1 Cincinnati Bengals head to Baltimore to take on the 3-1 Ravens in an AFC North showdown. This game could feature a ton of points as both offenses have been terrific this season.

Bengals rookie quarterback Joe Burrow has thrown for over 300 yards in two straight games, but Cincinnati can also run the ball. Running back Joe Mixon had three touchdown runs in the Week 4 win. 

After getting embarrassed by the Chiefs in Week 3, the Ravens bounced back in Week 4. Quarterback Lamar Jackson accounted for three touchdowns in the win, and the defense played better as well.

Baltimore will win this game, but the Bengals will cover and keep it close. 

Jacksonville Jaguars vs. Houston Texans

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Click here for: Jacksonville Jaguars at Houston Texans (-6.5) Betting Predictions

The Jacksonville Jaguars are 1-3 after losing two straight games, and the Houston Texans are still winless. Houston will also have Romeo Crennel as their new coach for this game after Bill O’Brien was fired after Week 4.

Jacksonville is led by quarterback Gardner Minshew, who threw for over 351 yards in Week 4. The Jaguars are looking for better play from their defense after giving up 33 points on Sunday.

Houston has been a mess on both sides of the ball, but there is still plenty of talent on that roster. Quarterback Deshaun Watson had 300 passing yards in Week 4, but the Texans must do a better job of protecting him.

This game won’t be pretty, but it will be the Texans that get their first win of the season on Sunday. 

Las Vegas Raiders vs. Kansas City Chiefs

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Click here for: Las Vegas Raiders at Kansas City Chiefs (-11.5) Betting Predictions

After looking great in the first two weeks, the Raiders have now dropped two straight games. Kansas City has been sharp all season long and is a perfect 4-0.

The Raiders continue to struggle on the defensive side of the ball, which will be a huge issue in this game. Quarterback Derek Carr had 311 passing yards in Week 4, but he can’t try to outscore the Chiefs.

Kansas City struggled offensively at times on Monday night against the Patriots, but Patrick Mahomes still threw a pair of touchdown passes. The Chiefs allowed just 10 points in that game, and that unit continues to play well.

This one will get out of hand in a hurry as the Chiefs roll to a 5-0 start. 

Los Angeles Rams vs. Washington Football Team

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Click here for: Los Angeles Rams (-8.5) at Washington Football Team Betting Predictions

The 3-1 Los Angeles Rams will take on the 1-3 Washington Football Team on Sunday in our nation’s capital. The Rams are a huge favorite in this game, and for good reason.

After struggling a season ago, Jared Goff and the Rams offense are back on track. Goff has been sharp all season long, and the Rams can put up a big number in this game.

Washington actually got 314 passing yards from quarterback Dwayne Haskins on Sunday, but it was not enough. The defense has been an issue this season, and that won’t change in this matchup.

The Rams have way too much talent, and they cruise to a big win in this one.

Philadelphia Eagles vs. Pittsburgh Steelers

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Click here for: Philadelphia Eagles at Pittsburgh Steelers (-7.5) Betting Predictions

Philadelphia earned its first win of the season on Sunday night by upsetting the San Francisco 49ers. The Pittsburgh Steelers had Week 4 off as their game with the Tennessee Titans was postponed.

Quarterback Carson Wentz continues to struggle with accuracy for the Eagles, but he did account for two touchdowns in Week 4. The defense played well on Sunday night, even scoring a touchdown in the win.

Pittsburgh has been airing it out this season now that Ben Roethlisberger is back and healthy. The defense has been tremendous as well, led by TJ Watt and his 3.5 sacks.

Philadelphia has momentum, but it won’t matter in this one as the Steelers win by double digits. 

Miami Dolphins vs. San Francisco 49ers

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Click here for: Miami Dolphins at San Francisco 49ers (-7.5) Betting Predictions

The 2-2 San Francisco 49ers will host the 1-3 Miami Dolphins on Sunday afternoon. San Francisco is dealing with several injuries, while the Dolphins are still in rebuilding mode.

Miami gave up 31 points in a Week 4 loss to the Seattle Seahawks, and its run defense will be tested in this one. The Dolphins still have Ryan Fitzpatrick playing quarterback, but Tua Tagovailoa is waiting. 

San Francisco scored just 20 points in Week 4, and they have major issues at the quarterback position. Jimmy Garoppolo is hurt, and the team will likely be forced to play CJ Beathard in this one.

The 49ers will win this game, but the Dolphins will keep it closer than the spread would indicate.

Indianapolis Colts vs. Cleveland Browns

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Click here for: Indianapolis Colts (-2.5) at Cleveland Browns Betting Predictions

A pair of 3-1 teams will meet up in Cleveland as the Browns are set to host the Indianapolis Colts. This game has the feel of a playoff preview as both teams are playing great football.

The Colts gave up just 11 points to the Bears in Week 4, and that unit is one of the best in the league. Rookie running back Jonathan Taylor has run the ball well for the Colts, and quarterback Philip Rivers knows how to win.

Cleveland went into Dallas on Sunday and put up 49 points in a blowout victory. The Browns still have some defensive issues, but that offense can score points in a hurry.

The Colts are the favorite in this game, but it will be the Browns that move to 4-1.

New York Giants vs. Dallas Cowboys

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Click here for: New York Giants at Dallas Cowboys (-9.5) Betting Predictions

The 0-4 New York Giants will take on the 1-3 Dallas Cowboys in an NFC East rivalry game on Sunday. These two teams have both struggled this season, and the NFC East is still up for grabs.

New York is playing without running back Saquon Barkley, and that has really hurt the offense. The Giants did hold the Rams to just 17 points in Week 4, and the defense will need to play great again.

Dallas is putting up some historically good offensive numbers, but the defense has been a disaster. Dak Prescott threw for 502 yards in Week 4, and that offense will have to carry Dallas in this one.

The Cowboys are too talented to continue to lose, and they will blow out the Giants in this matchup. 

Denver Broncos vs. New England Patriots

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Click here for: Denver Broncos at New England Patriots (-2.5) Betting Predictions

The Denver Broncos picked up their first win of the season on Thursday night against the New York Jets. New England has now lost two straight games and is heading in the wrong direction.

Brett Rypien led the Broncos offense with 242 passing yards and two touchdowns in the Week 4 win. Melvin Gordon had 107 rushing yards and two touchdowns in that win, and the offense must win this game for Denver.

The Patriots will likely be without quarterback Cam Newton in this game, which will really hurt the offense. New England got 100 rushing yards from Damien Harris in Week 4, and the Patriots will need to run the ball well in this game.

This game is hard to predict with so much unknown, but the Patriots win this game by more than a field goal. 

Minnesota Vikings vs. Seattle Seahawks

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Click here for: Minnesota Vikings at Seattle Seahawks (-7.0) Betting Predictions

The 1-3 Minnesota Vikings will take on the 4-0 Seattle Seahawks on Sunday Night Football in Week 4. This is viewed as one of the best games of the week, but the Vikings still have some work to do.

Minnesota went into Houston in Week 4 and came away with an impressive 31-23 victory. Running back Dalvin Cook had 130 yards and two rushing touchdowns in that win.

Seattle has been scoring points like crazy this season, led by quarterback Russell Wilson. Wilson has now thrown 16 touchdown passes through four games, tying an NFL record.

This game should be a high-scoring affair, but the Seahawks are simply too good for the Vikings. 

Monday, Oct. 12

Los Angeles Chargers vs. New Orleans Saints

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Click here for: Los Angeles Chargers at New Orleans Saints (-7.5) Betting Predictions

The New Orleans Saints will host the Los Angeles Chargers on Monday Night Football to wrap up Week 5. The Saints are 2-2 on the young season while the Chargers are just 1-3.

Los Angeles put up 31 points in a Week 4 loss to the Tampa Bay Buccaneers, and rookie quarterback Justin Herbert continues to play well. The Chargers will need a better defensive performance in this game.

Saints quarterback Drew Brees had two passing touchdowns in Week 4, but this offense is still missing Michael Thomas. The Saints will be looking to win this game in a shootout as the defense has struggled at times.

In a high-scoring affair, it will be the Saints winning this game by double digits. 

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