NFL Lines Week 2: Odds And Lines Comparisons At Major US Sportsbooks

• Football

What a wacky Week 1 of National Football League action we had.

Ten of the 14 Sunday games saw the underdogs cover, and there were some straight-up upsets as well, which was good for you if you had the money lines for those contests.

Is this the start of the new NFL?

Well, we will have to see about that: order could be restored as early as Week 2, although there are going to be a good chunk of games this week that end up with point spread lines somewhere between a pick and less than a touchdown, with many even closer.

Of course, you are going to get some double-digit lines as well: three games have already moved up to -11.5 (Green Bay hosting Detroit) or -12.5 (Atlanta at Tampa Bay and Houston at Cleveland).

Will we see any more upsets? Probably. Will they come from any of the games that will have touchdown-plus lines? Doubtful.

Here is a look at how to bet on NFL Week 2. 

NFL Odds & NFL Lines Week 2

If you are wondering how to bet on NFL at the start of the NFL season, which has just started, here you will see all the NFL odds for Week 2.

Undoubtedly, you will also find the most attractive NFL Betting Odds and NFL Lines Week 2.

Without further adieu, it's time to kick off an all-American favorite and the great fun of NFL betting that comes with it. Here are your updated NFL Odds and Lines Week 2, all in one place.

Check back daily to see updates.

For more NFL-related content, picks & predictions make sure to check our expert NFL Predictions page.

NFL Week 2 Opening (LOOKAHEAD) Spreads

GameLookahead lineCurrent spread
Giants at WashingtonWashington -3Washington -3
Raiders at SteelersSteelers -6Steelers -6.5
Bengals at BearsBears -4.5Bears -3
Texans at BrownsBrowns -13Browns -12.5
Rams at ColtsRams -2.5Rams -4
Bills at DolphinsBills -3Bills -3
Patriots at JetsPatriots -4.5Patriots -5.5
49ers at Eagles49ers -4.549ers -3.5
Saints at PanthersSaints -3Saints -3
Broncos at JaguarsBroncos -2.5Broncos -6
Vikings at CardinalsCardinals -1.5Cardinals -3.5
Falcons at BuccaneersBuccaneers -8Buccaneers -12.5
Cowboys at ChargersChargers -1Chargers -2.5
Titans at SeahawksSeahawks -4.5Seahawks -5.5
Chiefs at RavensChiefs -1Chiefs -3
Lions at PackersPackers -10Packers -11.5
NFL Week 2 Opening (LOOKAHEAD) Spreads

For more odds, make sure to check our NFL Betting Odds page.

NFL Week 2 Schedule

New York Giants (0-1) at Washington Football Team (0-1)

I talked about this in the Thursday Night Football preview article (which you can read in more depth about here), but this could be a massive game for both teams already in Week 2. Ryan Fitzpatrick is going to be out for six-to-eight weeks with a hip injury, so the Football Team is going to have to turn to Taylor Heinicke, who looked good in Sunday Night Football betting when he came off the bench in the 20-16 loss to the Chargers.

Well, better than the Giants’ offense looked at least. New York was awful against the Denver Broncos in a 27-13 loss and now has to hit the road in a short week. You have to like Washington in this spot.

Buffalo Bills (0-1) at Miami Dolphins (1-0), 1 p.m. EDT

What an intriguing contest this has become after Week 1. Buffalo was upset by Pittsburgh 23-17, after the Bills defense collapsed in the fourth quarter (allowed 17 points). Josh Allen threw 51 passes, but only for 270 yards and a single score.

Miami, meanwhile, picked up a huge 17-16 win over New England, powered in large part by its bend but don’t break, opportunistic defense. This is already a huge game for Buffalo, which can’t afford to fall to 0-2 this early. The Bills will show what they are made of in this contest.

Cincinnati Bengals (1-0) at Chicago Bears (0-1), 1 p.m. EDT 

Cincinnati stunned the Minnesota Vikings 27-24 in overtime, as Joe Mixon ran for 127 yards and a score. That might be more of an indictment of the NFC North, though, which is the lone division without a win after Week 1. But the Bengals do have some weapons.

Chicago hung with the LA Rams for the better part of three quarters on Sunday night, but the Rams pulled away for a 34-14 win, to finish off my Parlay Power Play of the week, moneyline edition, and win me some cash. Will Justin Fields get the ball? If he does, I am all over the Bears.

Denver Broncos (1-0) at Jacksonville Jaguars (0-1), 1 p.m. EDT

What a Week 1 win for the Denver Broncos, who went on the road and beat the Giants 27-13. Denver fans (and bettors) are not used to quick starts for the Broncos, but they might have to get used to it in 2021: they will be favored again on the road at Jacksonville, although by the slightest of margins for the second week running.

The Jaguars had the hype of Trevor Lawrence, but while he threw for 332 yards and three TDs, he also threw three INTs, and the Jags gave up 37 points to the lowly Houston Texans. What will Teddy Bridgewater do to this defense?

Houston Texans (1-0) at Cleveland Browns (0-1), 1 p.m. EDT

Break up those Texans, by the way. Houston, whose offseason was turmoil and tumult, came out and blew out the Jaguars 37-21. What a great start this season, which many thought might see them winning under four games: you are a quarter of the way there already!

The Browns had Kansas City on the ropes once again, but for the second straight game (albeit one with less on the line), Cleveland could not hold a 22-10 halftime lead. Against the Texans in their home opener, though, expect Cleveland to post big numbers. Now, whether that covers the two-touchdown spread or not is another story...

Los Angeles Rams (1-0) at Indianapolis Colts (0-1), 1 p.m. EDT

I cannot express enough how high I am on this LA team, which does not have to rely on its defense to always win games. Matthew Stafford was very impressive under center in his Rams’ debut, and while the defense allowed the Bears to move the ball, it shut the visitors down late when it had to.

Indianapolis was disappointing at home in a 28-16 loss to Seattle in Week 1, and gets another NFC West team at home in Week 2. I think the Rams are the best of the West and should be able to limit Carson Wentz and Jon Taylor. 

Las Vegas Raiders (1-0) at Pittsburgh Steelers (1-0), 1 p.m. EDT

It was a Monday night win for the Raiders in overtime, 33-27, as they opened their new stadium (with fans) in style. David Carr had a monster night, throwing for 435 yards and two TDs, while Josh Jacobs ran for two more scores.

I was very impressed by the Steelers, who you have to remember went 12-4 in 2020. Pittsburgh scored 17 points in the fourth quarter, and 23 in the second half (after it was shutout in the first half) in a 23-17 win over AFC finalist Buffalo. The question now becomes, can the Steelers do it again, against a team on a short week traveling across the country? You have to like that spot.

New England Patriots (0-1) at New York Jets (0-1), 1 p.m. EDT

Mac Jones is going to be the guy in New England, but he could not get it done in Week 1 against the Dolphins in a 17-16 loss. The rookie did throw for 281 yards, and Damian Harris had 100 yards rushing, so there is not too much to tweak.

The Jets got a decent first game from their rookie QB, Zach WIlson (258 yards, 2 TDs), and nearly came back to overturn a 16-0 halftime deficit in Carolina. This might actually be a very intriguing contest, but it is very tough to bet: I might look at the under here.

New Orleans Saints (1-0) at Carolina Panthers (1-0), 1 p.m. EDT

Two of the three teams in the NFC South that won their first game will meet in Week 2. “Famous” Jameis Winston threw for five TDs as he took over for Drew Brees, in a 38-3 blowout win over the Green Bay Packers. New Orleans’ defense played outstanding.

Carolina jumped out to a 16-0 lead, as the Sam Darnold era began. But the Jets came storming back, although their comeback fell short in a 19-14 loss. The Panthers are going to do it with defense, so Winston needs to take care of the ball.

San Francisco 49ers (1-0) at Philadelphia Eagles (1-0), 1 p.m. EDT

San Francisco scored 41 points on the road and took a 28-point lead in Detroit, but all the talk after was the near collapse. But that might be a but misguided: the 49ers posted nearly 450 yards of offense, Jimmy Garoppolo completed 17-of-25 for 314 yards, Elijah Mitchell took over for an injured Raheem Mostert ran for 104 yards, and Deebo Samuel had 189 yards receiving.

The Eagles had one of the easiest wins of the weekend, 32-6 over the hapless Falcons. Jalen Hurts was fantastic, DeVonta Smith had 71 yards receiving, and the defense was stout. But this could be a step up in class.

Atlanta Falcons (0-1) at Tampa Bay Buccaneers (1-0), 4:05 p.m. EDT

I might be reading too much into this after the first week, but the Atlanta Falcons might stink, and the Tampa Bay Buccaneers do not. Well, maybe the defense needs to pick it up a little bit, but Tom Brady is already in mid-season form after he led his team down the field to kick a game-winning field goal in a 31-29 win over Dallas.

Atlanta got blown out at home 32-6 by the Eagles, so Brady and company must be licking their lips to get out there against the Falcons. This has Bucs big blowout all over it: get it before the line goes above -14.

Dallas Cowboys (0-1) at Los Angeles Chargers (1-0), 4:25 p.m. EDT

Dallas gave Tampa Bay all it could handle in a 31-29 opening night loss, with Dak Prescott going for 403 yards. The offense under Prescott has never been an issue: it has always been the defense. If Tampa didn’t turn the ball over four times, the Bucs might have posted 50 points.

Los Angeles has a tough offense as well, with Justin Herbert (337 yards) leading the way under center. The Chargers came East and got a big 20-16 win, and now gets another NFC East team in what could be the best game of the later window.

Minnesota Vikings (0-1) at Arizona Cardinals (1-0), 4:05 p.m. EDT

Oh, those Minnesota Vikings: you never know what you are going to get, which is one of the reasons I tend to stay away from them when betting: teams that have no patterns are very tough to figure out, obviously.

But the Cardinals are not: this is a team that is ever-improving and blew out the Titans in Tennessee 38-13. Kyler Murray has a legit MVP shot if this team wins 10-11 games, and he had 289 and four TD passes on opening day, two to DeAndre Hopkins. Chandler Jones also had FIVE sacks! Best bet material here.

Tennessee Titans (0-1) at Seattle Seahawks (1-0), 4:25 p.m. EDT 

I am not as high on Tennessee, but I guess some team has to win the AFC South. The Titans got steamrolled by Arizona at home, and were never in the contest. 

Once again, they have another NFC West team, but this time it is on the road. Seattle went to Indy and won big, and Russell Wilson must be rubbing his hands to get out there on the turf for this one.

Kansas City Chiefs (1-0) at Baltimore Ravens (0-1), 8:20 p.m. EDT 

Kansas City showed why it has been the best team in the AFC for the last three seasons, coming back from 22-10 down at halftime to beat a good Cleveland team. Tyreek Hill had 197 yards receiving, and Patrick Mahomes was Patrick Mahomes.

Baltimore gave up 23 points in the fourth quarter and overtime, including a last-second, game-tying field goal, and now has to get up off the floor on a short week and face the best offensive team in the game, Yikes!

Read more about this game here in our Sunday Night Football Betting guide.

Detroit Lions (0-1) at Green Bay Packers (0-1), 8:15 p.m. EDT

Amazingly, the Lions had the better showing on Week 1, nearly coming back from a 28-point deficit in a 41-33 loss to the 49ers. Jared Goff had 338 yards passing, but you have to take that comeback with a slight grain of salt: San Fran might have eased up.

The Packers eased up from the opening whistle, watching all day as Jameis Winston tore them to shreds in a 38-3 humbling. Is there a problem in Green Bay? We will know soon: this should be a two-touchdown minimum win, but will it be?

Read more about this game in detail, in our Monday Night Football Betting guide.


NFL Betting Lines Week by Week Index

Check out our NFL Betting Lines provided by proven experts. See their success rates and what lies ahead in the future.

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