NFL Week 2 Odds: Betting Lines At Major US Sportbook Apps - HowToBet

NFL Week 2 Odds And Lines Comparisons At US Sportsbooks

The first weekend of the NFL season came and went, and there were very few surprises. Football stadiums were mostly empty throughout the country, but the play on the field was still great as usual.

Teams will now look ahead to Week 2, and this will be a chance for teams to either turn things around or pick up where they left off in Week 1.

Also see: Best Week 2 Offers From Us Sportsbooks 

NFL Week 2 Odds And Analysis

Cincinnati Bengals at Cleveland Browns (-5.5)

The Cleveland Browns and Cincinnati Bengals will kick off the Week 2 slate with a matchup on Thursday Night Football. Both teams come into this contest with a record of 0-1.

Cleveland suffered a 38-6 defeat at the hands of the Baltimore Ravens in Week 1, and not much went right. Cincinnati lost a heartbreaking 16-13 decision to the Los Angeles Chargers, but this team showed some signs of progress.

This game will feature a matchup of former Heisman Trophy-winning quarterbacks. Baker Mayfield is entering his third season with the Browns, and rookie Joe Burrow is leading the Bengals.

These two teams combined to score just 19 points in Week 1, and this has all the makings of a low-scoring game. 

Atlanta Falcons at Dallas Cowboys (-5.0)

The Dallas Cowboys suffered a disappointing Week 1 loss to the Los Angeles Rams, but they head home on Sunday as five-point favorites over the Atlanta Falcons. Atlanta is also 0-1 so far on the season after losing 38-25 to Seattle in Week 1.

Falcons quarterback Matt Ryan threw for 450 yards in the loss, but Atlanta simply couldn’t find enough defense. Atlanta will look for more balance on this game against the Cowboys.

Dallas managed to score just 17 points in their Week 1 loss to the Los Angeles Rams. Ezekiel Elliott ran for 95 yards and a touchdown, but the Cowboys need a better passing attack. 

Buffalo Bills (-5.5) at Miami Dolphins

AFC East rivals square off in Miami in Week 2 as the Buffalo Bills are 5.5-point favorites over the Miami Dolphins. Buffalo enters the game with a 1-0 record while the Miami Dolphins suffered a defeat in Week 1.

Buffalo was a popular preseason pick to win the AFC East, and the Bills looked the part in Week 1. Quarterback Josh Allen threw for 312 yards, and the Bills cruised to victory over the New York Jets.

Miami gave the Patriots a battle in Week 1 but ended up scoring just 11 points in defeat. The Dolphins still have veteran Ryan Fitzpatrick under center, but rookie Tua Tagovaioloa is lurking. 

Carolina Panthers at Tampa Bay Buccaneers (-7.5)

A pair of 0-1 NFC South teams will square off in Tampa Bay as the Buccaneers host the Carolina Panthers. Tampa Bay is a 7.5-point favorite in this game despite suffering a double-digit loss in Week 1.

The Tampa Bay debut for quarterback Tom Brady did not go as expected, as Brady threw a pick-six in the loss. Tampa Bay also allowed 34 points to the New Orleans Saints, and this defense continues to be a question mark.

Carolina put up 30 points on offense in Week 1, and new quarterback Teddy Bridgewater had a big day. The Panthers are a much-improved team, but they still have a long way to go. 

Denver Broncos at Pittsburgh Steelers (-6.0)

The Pittsburgh Steelers are six-point favorites over the Denver Broncos in Week 2. Both the Steelers and Broncos played on Monday night, so both will have a short week to prepare.

Pittsburgh earned a 26-16 victory over the New York Giants, and their rushing defense led the way. The Steelers held star running back Saquon Barkley to just six rushing yards on 15 carries.

Denver scored just 14 points in a loss to the Tennessee Titans, and the new-look offense struggled at times. The Broncos can really defend, but at some point, this team has to find the end zone. 

Detroit Lions at Green Bay Packers (-5.5)

NFC North rivals collide in Week 2 as the Green Bay Packers host the Detroit Lions. Green Bay won the NFC North in 2019, and it is a 5.5-point favorite in this game.

Green Bay went into Minnesota as a 2.5-point underdog and came away with a 43-34 victory in Week 1. Quarterback Aaron Rodgers threw for 364 yards and four touchdown passes in that victory.

Detroit dominated the Chicago Bears for three quarters, but they were outscored 21-0 in the fourth quarter and lost. Running back Adrian Peterson racked up 93 yards on the ground, but the Lions defense needs to improve. 

Jacksonville Jaguars at Tennessee Titans (-10.5)

AFC South rivals square off in Week 2 as the Tennessee Titans host the Jacksonville Jaguars. Both teams come into this game with records of 1-1, but it is the Titans that are big favorites.

Running back Derrick Henry had 116 yards on 31 carries for the Titans in Week 1, and they will look to run the ball in this game. Kicker Stephen Gostkowski missed four kicks in the opener but nailed a game-winner late in the fourth quarter.

Jacksonville quarterback Gardner Minshew had three touchdown passes in the win over the Indianapolis Colts in Week 1. The Jaguars were also solid on defense, but their run defense will get a test in this game. 

Los Angeles Rams at Philadelphia Eagles (-1.0)

One of the best matchups in Week 2 will take place in Philadelphia as the Eagles host the Los Angeles Rams. Philadelphia suffered a loss in Week 1, while the Rams beat the Dallas Cowboys on Sunday Night Football. 

Philadelphia held a 17-0 lead over the Washington Football Team but then allowed their opponent to score 27 unanswered points. Quarterback Carson Wentz threw for 270 yards and two touchdowns in the loss but also had a costly turnover late.

The Rams used a 275-yard passing performance from Jared Goff to hold off the Dallas Cowboys in Week 1. Defensive tackle Aaron Donald and his teammates were great on defense in the win. 

Minnesota Vikings at Indianapolis Colts (-3.0)

Both the Minnesota Vikings and Indianapolis Colts were favored in Week 1, but both teams suffered a defeat. Minnesota got torched by the Green Bay Packers, while the Colts lost to the lowly Jacksonville Jaguars.

Minnesota had almost 400 yards of total offense in Week 1, but its defense really let it down. The Vikings allowed Green Bay to throw for 364 yards, and the team struggled to find a pass rush.

Colts quarterback Philip Rivers threw for 343 yards in the Week 1 loss but also threw a costly interception late in the fourth quarter. The Colts will be without starting running back Marlon Mack for the remainder of the season due to injury. 

New York Giants at Chicago Bears (-5.5)

The Chicago Bears head home to take on the New York Giants in Week 2, and the Bears are 5.5-point favorites. This is a matchup of two young quarterbacks, and both players have plenty to prove. 

Mitchell Trubisky of the Chicago Bears threw three fourth-quarter touchdowns in Week 1 to propel the Bears to a comeback win. Chicago’s vaunted defense struggled at times, but it will attack a young quarterback for New York.

Daniel Jones had a big night for the Giants in Week 1, but he also struggled with turnovers. Running back Saquon Barkley failed to reach 10 rushing yards, and he must be better in this game. 

San Francisco 49ers (-7.0) at New York Jets

The New York Jets will host the San Francisco 49ers on Sunday, and one of these teams will get their first win of the season. San Francisco is a huge seven-point road favorite, but the 49ers struggled in Week 1.

Quarterback Jimmy Garropolo had 259 passing yards and two touchdowns for the Niners in the Week 1 loss, but this team struggled to get its running game going. The Niners also struggled to defend the run, two things that they were great at a season ago.

Wide receiver Jamison Crowder had seven catches for 115 yards in the season-opening loss for the Jets, but this offense struggled at times. New York has plenty of room for improvement heading into this Week 2 game.

Washington Football Team at Arizona Cardinals (-6.5)

Two teams that pulled off upsets in Week 1 will square off in Arizona as the Cardinals host the Washington Football Team. Washington stunned the Philadelphia Eagles in Week 1, and the Cardinals were impressive winners over the San Francisco 49ers.

Washington managed less than 240 yards of total offense in Week 1, but it was enough for a comeback win over the Philadelphia Eagles. Quarterback Dwayne Haskins Jr. threw for 178 yards, but he needs to play better in this game.

Wide receiver DeAndre Hopkins had 14 catches for 151 yards in his Cardinals debut, and quarterback Kyler Murray ran for 91 yards and a score. This Cardinals team can score points in a hurry. 

Baltimore Ravens (-6.5) at Houston Texans

After taking on the defending Super Bowl champions in Week 1, the Houston Texans head home to face a team that went 14-2 a season ago. Baltimore is a 6.5-point road favorite in Week 2, and this team put on an impressive showing in Week 1.

Reigning MVP Lamar Jackson threw for 275 yards and three touchdowns in the 38-6 victory over the Cleveland Browns. It was the defense of Baltimore that stole the show in the season opener.

Houston quarterback Deshaun Watson and wide receiver Will Fuller connected eight times for 112 yards in the season opener, but the Texans struggled to find much offense. The Texans will need their defense to be great in this game. 

Kansas City Chiefs (-8.5) at Los Angeles Chargers

The Kansas City Chiefs travel to Los Angeles to take on their division rivals in the Los Angeles Chargers in Week 2. Both teams were victorious in Week 1, but the Chiefs looked much more dominant.

Rookie running back Clyde Edwards-Helaire had 138 rushing yards and one touchdown in the Week 1 win, and the Chiefs looked in midseason form in their win over the Houston Texans. Oh, and that passing attack is pretty explosive for Kansas City as well.

The Chargers got a 16-13 win over the Cincinnati Bengals in Week 1, and quarterback Tyrod Taylor was just good enough. Taylor threw for 208 yards in the win, but the Chargers will need more offense against the Chiefs.

New England Patriots at Seattle Seahawks (-4.0)

Playoff contenders clash in Seattle on Sunday night as the Seahawks host the New England Patriots. Both teams won their season openers and looked impressive in doing so. 

Quarterback Cam Newton had 75 rushing yards and two touchdowns in the Week 1 victory, and the Patriots unveiled a new-look offense. New England was once again solid on defense, which was its strength a season ago.

Seattle will go as far as quarterback Russell Wilson can take them, and he had four touchdowns against the Falcons in Week 1. The Seahawks no longer feature the “Legion of Boom,” but this is still a formidable defense. 

Monday, September 21

New Orleans Saints (-5.5) at Las Vegas Raiders

Monday Night Football will feature a pair of 1-0 teams, and it will also be the first game for the Raiders at their new home in Las Vegas. The Raiders will be the 5.5-point underdogs in Week 2 as they are hosting one of the favorites to win the Super Bowl.

Las Vegas kicked off its 2020 season with a 34-30 win over the Carolina Panthers. Running back Josh Jacobs ran for three touchdowns in that game, and quarterback Derek Carr had 239 passing yards.

The Saints also scored 34 points in their season opener and hung on to beat the Tampa Bay Buccaneers by a score of 34-23. New Orleans has an explosive offense, and its defense scored a touchdown in the season opener.

Look for this game to be one of the highest-scoring games in Week 2. 


Let's have a look at the current NFL Week 2 spreads compared to where they opened last week.

MatchupOpening lineCurrent line (Sept. 15)
Cincinnati at ClevelandBrowns -7.5Browns -6.5
Atlanta at DallasCowboys -7Cowboys -6.5
Buffalo at MiamiBills -3Bills -5.5
Carolina at Tampa BayBuccaneers -8.5Buccaneers -7.5
Denver at PittsburghSteelers -5.5Steelers -6
Detroit at Green BayPackers -6Packers -5.5
Jacksonville at TennesseeTitans -10.5Titans -10.5
LA Rams at PhiladelphiaEagles -4Eagles -3
Minnesota at IndianapolisColts -3Colts -3
NY Giants at ChicagoBears -5Bears -5.5
San Francisco at NY Jets49ers -649ers -7
Washington at ArizonaCardinals -6.5Cardinals -6.5
Baltimore at HoustonRavens -5.5Ravens -6.5
Kansas City at LA ChargersChiefs -6.5Chiefs -8.5
New England at SeattleSeahawks -3.5Seahawks -4
New Orleans at Las VegasSaints -4.5Saints -4.5
About Ayden Fahlstrom
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Ayden loves sports. There is no doubt about that. He is a walking calendar when it comes to the latest events in sports. He has grown into the passion of writing about them, and settled into his role as a writer after many freelancing jobs. He can write about any sport out there! This is the guy!

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