NFL Week 16 Betting Lines & Odds Comparisons At Legal US Sportsbooks

NFL Week 16 Betting Lines, Live Odds Comparisons At US Sportsbooks

Also see: Best NFL Week 16 Offers From Us Sportsbooks 

It's time for Week 16 of the NFL season, meaning there are just two games remaining for each team. Playoff races are heating up in each conference, and there will be plenty of important games around the league this week.

There will also be four straight days of NFL football in Week 16 as there will be a game played on Christmas night. Here is a look at all 16 games on the schedule this weekend, with a brief betting preview of each game.

Thursday, Dec. 17

Click here for Minnesota Vikings at New Orleans Saints (-7.0) Betting Predictions

The 10-4 New Orleans Saints host the 6-8 Minnesota Vikings on Friday night to kick off the Week 16 action. Minnesota is barely holding on to life in the playoff race, while the Saints are trying to wrap up the NFC South.

Minnesota running back Dalvin Cook has run for 1,484 yards and 15 touchdowns this season, but he hasn't gotten a lot of help. The Vikings have also struggled mightily on defense, and that will be a problem in this game.

New Orleans has now lost two straight games, including a loss with Drew Brees under center in Week 15. The Saints don't throw the ball well, but running back Alvin Kamara can take over a game.

The Saints are going to figure out their offense at some point, and it will happen on Friday night. Take the New Orleans Saints -7.0 over the Minnesota Vikings on Christmas. 

Saturday, Dec. 26

Click here for Tampa Bay Buccaneers (-9.5) at Detroit Lions Betting Predictions

The 9-5 Tampa Bay Buccaneers will take on the 5-9 Detroit Lions in one of three games scheduled for Saturday in Week 16. This could be a high-scoring affair as both teams love to throw the football a ton.

Bucs quarterback Tom Brady has thrown for 3,886 yards and 32 touchdowns, but he has struggled a bit with his consistency. Tampa Bay has a dominant defensive line, and that unit will need to play well in this one.

Detroit quarterback Matthew Stafford is battling through an injury, and that has hurt this offense. The Lions are one of the worst defensive teams in the league, and that's a bad matchup against Tampa Bay.

The Bucs can still win the NFC South, and they will take care of business on Saturday. Look for Tampa Bay to take control of this game early and cover the 9.5-point spread.

Click here for San Francisco 49ers at Arizona Cardinals (-4.5) Betting Predictions

NFC West rivals will meet up in Arizona for a rematch of the 2020 season opener. The Arizona Cardinals have improved to 8-6 on the year while the San Francisco 49ers have slipped to 5-9.

Injuries have derailed the 49ers season, and the defense has started to fall apart of late. San Francisco has gotten solid play from quarterback Nick Mullens, but there just aren't enough weapons.

Cardinals quarterback Kyler Murray has thrown for 3,637 yards, and DeAndre Hopkins has 103 receptions for more than 1,300 yards. Arizona will give up some points on defense, but that offense is extremely hard to stop. 

San Francisco is just dealing with too many injuries, and it can't keep up in this one. Bet the Cardinals -4.5 as they move one game closer to a playoff berth. 

Click here for Miami Dolphins (-2.5) at Las Vegas Raiders Betting Predictions

The final game on Saturday will feature a pair of playoff hopefuls in the AFC. The Miami Dolphins enter Week 16 with a 9-5 record while the Las Vegas Raiders have slipped to just 7-7.

Miami has one of the best defenses in the NFL this season, and it has been great at forcing turnovers. Rookie quarterback Tua Tagovailoa has been a bit inconsistent, but he has provided a spark to this offense.

The Las Vegas Raiders could be without quarterback Derek Carr as he was injured in the Week 15 loss. Running back Josh Jacobs will have to play a large role if Carr is unable to go in this game.

Las Vegas is heading in the wrong direction, and that should let Miami take control of this one. Bet the Dolphins -2.5 over the Raiders on Saturday night. 

Sunday, Dec. 27

Click here for Chicago Bears (-7.5) at Jacksonville Jaguars Betting Predictions

The Chicago Bears have suddenly found some offense, and they look to keep their playoff hopes alive this weekend in Jacksonville. Chicago is now 7-7 on the season, while the Jacksonville Jaguars are just 1-13.

Quarterback Mitchell Trubisky and running back David Montgomery have both been on a roll for the Bears, and the offense has scored at least 33 points in back-to-back weeks. The defense has regressed a bit, but that unit can still get after the quarterback.

Jacksonville has now lost 13 straight games, and it currently holds the No. 1 overall pick in the 2021 NFL Draft. Losing is the best option for the Jaguars moving forward, and it's something that they are very good at.

This game won't be close as the Chicago Bears blow this one out and cover the 7.5-point spread. 

Click here for Atlanta Falcons at Kansas City Chiefs (-10.0) Betting Predictions

The 13-1 Kansas City Chiefs host the 4-10 Atlanta Falcons on Sunday at Arrowhead Stadium. If you are a fan of offense, then this is the game that you will want to watch.

Quarterback Matt Ryan has thrown for more than 4,000 yards this year, and the Falcons are a challenge for any defense. Atlanta just continues to blow late leads, but that likely won't be an issue in this one.

Patrick Mahomes has thrown for more than 4,440 yards for the Chiefs, who will look to exploit a struggling secondary. The Chiefs will be without rookie running back Clyde Edwards-Helaire, who is out with an ankle injury.

Losing Edwards-Helaire is a tough blow, but it won't slow down the Chiefs. Take Kansas City -10.0 over Atlanta in Week 16. 

Click here for Cleveland Browns (-9.5) at New York Jets Betting Predictions

The surging Cleveland Browns will take on the improving New York Jets on Sunday in the Meadowlands. Cleveland brings a 10-4 record into this game, while the Jets won on Sunday to improve to 1-13.

Cleveland loves to run the football, and it has a pair of great running backs in Kareem Hunt and Nick Chubb. The defense is very aggressive, and the Browns suddenly look like a Super Bowl contender.

The Jets stunned the Los Angeles Rams on Sunday, and the defense was able to slow down a great offense. New York is still looking for more offense, especially from quarterback Sam Darnold. 

New York will bring some momentum into this game, but that momentum won't be enough. Bet the Cleveland Browns -9.5 over the New York Jets. 

Click here for Indianapolis Colts at Pittsburgh Steelers (-2.0) Betting Predictions

The 11-3 Pittsburgh Steelers host the 10-4 Indianapolis Colts in what could be a potential playoff preview in the AFC. The Colts were winners in Week 15, while the Steelers were upset by the Cincinnati Bengals on Monday Night Football.

Colts quarterback Philip Rivers has thrown for over 3,700 yards this season, and this team will take some shots down the field. Indianapolis also has a solid defense, led by linebacker Justin Leonard.

The Steelers have now lost three straight games, and the offense has been a major issue. Pittsburgh's defense should play well, but Ben Roethlisberger needs to find his top targets on Sunday.

Pittsburgh is too good to continue to struggle, and it will turn things around on Sunday. Take the Steelers -2.0 over the Indianapolis Colts. 

Click here for Carolina Panthers at Washington Football Team (-2.5) Betting Predictions

The 6-8 Washington Football Team hosts the 4-10 Carolina Panthers in a game with huge playoff implications. The Panthers will be looking to play the role of spoiler as Washington tries to stay atop the NFC East.

Carolina quarterback Teddy Bridgewater has thrown for 3,360 yards this season, and the Panthers have some great wide receivers. Defense has been an issue for Carolina, and that could cause problems on Sunday.

The Washington Football Team will likely have Dwayne Haskins back under center as Alex Smith is dealing with an injury. Washington has been scoring points of late, but the real strength of the team is on defense.

Washington needs this win, and it will find a way to get it. Take the Washington Football Team -2.5 over the Carolina Panthers. 

Click here for New York Giants at Baltimore Ravens (-10.5) Betting Predictions

A pair of potential playoff teams will meet up in Baltimore on Sunday as the 9-5 Ravens host the 5-9 New York Giants. New York has slipped a bit in the NFC East while the Ravens are trying to climb into the AFC playoff picture.

New York has really struggled on offense this season, and it could be Colt McCoy back under center in this game. The Giants did hold the Browns to just 20 points in Week 15, and that defense will need to be great again.

Ravens quarterback Lamar Jackson has run for 828 yards this season, but he still struggles to throw the ball. Baltimore has been getting great play from its defense, and that could be a key in this one.

Baltimore is going to win this game, but the Giants will keep it close. Take the 10.5 points and bet on the New York Giants on Sunday to cover the spread. 

Click here for Cincinnati Bengals at Houston Texans (-7.5) Betting Predictions

The Houston Texans host the Cincinnati Bengals in a matchup of disappointing teams in 2020. Houston brings a 4-10 record into this game while the Cincinnati Bengals are 3-10-1. 

Cincinnati did just pull off a stunning win over the Steelers on Monday Night Football, and its defense played great. Running back Giovanni Bernard was also great in that matchup, scoring a pair of touchdowns. 

Houston quarterback Deshaun Watson has thrown for over 4,100 yards this season, but the Texans still can't win. The offensive line is a real problem, and the defense has been a major disappointment.

Even though the Texans have struggled, their offense will be too good in this game. Take the Houston Texans -7.5 over the Cincinnati Bengals. 

Click here for Denver Broncos at Los Angeles Chargers (-3.0) Betting Predictions

AFC West rivals meet up in Los Angeles on Sunday, and there will be two young quarterbacks leading the way. Both teams are just 5-9 on the season, and the Broncos earned a 31-30 win over the Chargers earlier in the season.

Denver suffered a 48-19 loss to the Buffalo Bills in Week 15, and it wasn't very competitive in that matchup. Quarterback Drew Lock has shown signs of improvement, but the Broncos struggle to score.

Chargers quarterback Justin Herbert has thrown for more than 3,700 yards this season, and he isn't afraid to take chances. Wide receiver Keenan Allen is nearing 1,000 receiving yards, and he will be a big key in this game. 

Look for the Chargers to get some revenge on Sunday as they win this one. Bet on the Los Angeles Chargers -3.0 over the Denver Broncos.

Click here for Philadelphia Eagles (-1.5) at Dallas Cowboys Betting Predictions

The NFC East race is still wide open, and this game will have a lot to do with the eventual outcome. The 5-9 Dallas Cowboys host the 4-9-1 Philadelphia Eagles in what could be a high-scoring affair.

Rookie quarterback Jalen Hurts has provided a spark for the Eagles, but it wasn't enough in Week 15. Hurts is a dual-threat at that position, but he will need some help to knock off Dallas.

The Cowboys continue to be terrible on defense, but the offense has started to come alive. Running back Ezekiel Elliott has run for 832 yards, and he will need to have a monster day in this one if he's able to play.

Both teams still have plenty of flaws, but Hurts gives the Eagles a huge boost. Take the Philadelphia Eagles -1.5 over the Dallas Cowboys on Sunday.

Click here for Los Angeles Rams at Seattle Seahawks (-3.0) Betting Predictions

The NFC West race is coming down to the final two weeks, but it could end with a Seahawks win on Sunday. Seattle comes into this game with a 10-4 record, while the Los Angeles Rams are just 9-5.

Los Angeles was stunned by the New York Jets in Week 15, and the offense really sputtered. Jared Goff threw for just 209 yards in the loss, and the Rams will need some offense in this matchup.

Seahawks quarterback Russell Wilson has thrown for 3,806 yards and 37 touchdowns, but he has slowed down his production of late. Seattle has struggled on defense for much of the season, but that unit must play well in this game.

Expect a ton of points in this matchup, but it will be Seattle that takes control. Bet the Seahawks -3.0 over the Los Angeles Rams. 

Click here for Tennessee Titans at Green Bay Packers (-3.5) Betting Predictions

Two of the top teams in the NFL will meet up in Week 16 on Sunday night. It will be the 11-3 Green Bay Packers hosting the 10-4 Tennessee Titans.

Tennessee is looking to win the AFC South this season, but it needs a win in this game. Running back Derrick Henry has been a monster this season, running for 1,679 yards and 15 touchdowns.

Packers quarterback Aaron Rodgers has thrown for 3,828 yards and 40 touchdowns and might be the MVP of the league. Green Bay struggles on the defensive side of the ball, but that offense can score in a hurry.

Green Bay is on a roll right now, and it will win this game. Take the Packers -3.5 over the Tennessee Titans on Sunday night. 

Monday, Dec. 28

Click here for Buffalo Bills (-7.0) at New England Patriots Betting Predictions

Week 16 of the NFL season will conclude with a Monday Night Football matchup between AFC East rivals. The 6-8 New England Patriots will host the 11-3 Buffalo Bills in what could be an exciting game.

Buffalo quarterback Josh Allen has thrown for 4,000 yards and 30 touchdowns to power the Bills offense. This team continues to improve, and it is a real threat to win the Super Bowl in 2020.

The New England Patriots have been eliminated from the playoffs, and it might be time to change quarterbacks. New England just hasn't found enough offense this season, but its defense remains strong.

Buffalo is now the clear leader of the AFC East, and they will put that on display on Monday Night Football. Take the Bills -7.0 over the Patriots in Week 16. 

Was this article helpful?

2 People have found this article helpful. Your feedback helps us improve our work.

message icon background
Join Our Tribe

Get all the latest sports news, expert tips and reviews.

Accept Cookies

To improve your user experience, we use cookies on our website. By continuing to use the service, you accept the use of cookies and our privacy policy.

Additional Information
responsible 18responsible 21responsible 21 - Sports Betting & USA Online Gambling Guides

We are committed to sharing our expert betting knowledge so you can have a winning chance against the bookie, the house or even naming the winner of the next Dancing with the stars. is part of Raketech Group - licensed and operating in PA, NJ, IN, CO, WV, MI, TN, IL, VA. Address: 263 Shuman Blvd Ste. 145, Naperville, IL 60563, United States

Disclaimer: It is your responsibility to check gambling regulations in your jurisdiction. does not accept responsibility for factual errors that may be evident. The site contains commercial content. This website is not responsible for third-party privacy policies.