NFL Week 16 Betting Lines, Live Odds Comparisons At US Sportsbooks

• Football
• NFL

It was going to happen at some point.

If you remember back to the 2020 National Football League season, games were moved all over the place due to COVID-19 outbreaks. We had Tuesday afternoon and night games, and even a Wednesday game.

But what we did not have were cancellations: every game was played, and the NFL got through its most challenging campaign.

So what did the NFL do for 2021? Well, the league added another game to the slate for each team.

We got to Week 15 of the season without too much disruption, but this week has been chaos. With the new highly-transmissible Omicron variant, players all over the NFL were testing positive for COVID-19. But it is not just the NFL; look at the English Premier League right now, which had games postponed all over the country and up and down the football pyramid last week. The NBA, NHL, and other sports are dealing with the new normal as well.

But the NFL just moved the games to another day, which is great for bettors of the sport, and got on with Week 15, playing two games Monday and two more on Tuesday.

The league also changed the protocols, so it is highly unlikely there will be games moved for Week 16, 17, and 18.

So what does that mean? Well, I hope you enjoy your Christmas week of NFL action on Monday, Tuesday, Thursday, Saturday, Sunday, and Monday, because it most likely will not happen again.

There are some massive games in Week 16. Some teams are trying to lock up division titles, while others are either trying to stay ahead of other teams, or trying to pull the pack back to them in the race for the final playoff places.

You are going to read this a lot in this story, but there are a lot of teams right now that could be VERY DANGEROUS if they get in, or if they can manage to win a division. Off the top of my head, I would include the Kansas City Chiefs (duh), Indianapolis Colts, Dallas Cowboys, LA Rams, and San Francisco 49ers on that list. All of those teams have had their struggles this year at times, and all could go into the playoffs on rolls.

Here is a look at all the odds and games for NFL Week 16.

NFL WEEK 16 ODDS 

Here are your updated NFL Week 10 odds, all in one place. Check back daily to see updates.

NFL Week 16 Opening (Lookahead) Spreads

  • San Francisco 49ers +1 at Tennessee Titans -1
  • Cleveland Browns +6.5 at Green Bay Packers -6.5
  • Indianapolis Colts +4 at Arizona Cardinals -4
  • Buffalo Bills +2 at New England Patriots -2
  • LA Rams -3 at Minnesota Vikings +3
  • Detroit Lions +6 at Atlanta Falcons -6
  • LA Chargers -10.5 at Houston Texans +10.5
  • Jacksonville Jaguars +1 at New York Jets -1
  • Baltimore Ravens +2.5 at Cincinnati Bengals -2.5
  • New York Giants +8.5 at Philadelphia Eagles -8.5
  • Tampa Bay Buccaneers -11 at Carolina Panthers +11
  • Chicago Bears +7 at Seattle Seahawks -7
  • Denver Broncos -1 at Las Vegas Raiders +1
  • Pittsburgh Steelers +9.5 at Kansas City Chiefs -9.5
  • Washington Football Team +9 at Dallas Cowboys -9

NFL Week 16 Updated (Lookahead) Spreads

  • San Francisco 49ers -3.5 at Tennessee Titans +3.5
  • Cleveland Browns +7.5 at Green Bay Packers -7.5
  • Indianapolis Colts +2 at Arizona Cardinals -2
  • Buffalo Bills +2.5 at New England Patriots -2.5
  • LA Rams -3 at Minnesota Vikings +3
  • Detroit Lions +4.5 at Atlanta Falcons -4.5
  • LA Chargers -10.5 at Houston Texans +10.5
  • Jacksonville Jaguars +2.5 at New York Jets -2.5
  • Baltimore Ravens +2.5 at Cincinnati Bengals -2.5
  • New York Giants +10 at Philadelphia Eagles -10
  • Tampa Bay Buccaneers -14 at Carolina Panthers +14
  • Chicago Bears +7 at Seattle Seahawks -7
  • Denver Broncos -1 at Las Vegas Raiders +1
  • Pittsburgh Steelers +10.5 at Kansas City Chiefs -10.5
  • Washington Football Team +10 at Dallas Cowboys -10

WEEK 16 SCHEDULE 

Thursday, Dec. 23

San Francisco 49ers (8-6) at Tennessee Titans (9-5) 8:20 p.m. EDT (NBC and fubo.TV)

This might be the game of the week, and we get it on Thursday night once again.

These two teams come into the contest in opposite trajectories: the 49ers are red hot, and have won five of six to become a VERY DANGEROUS team in the playoffs, if they get in. Tennessee has lost three of four, but could still yet be a VERY DANGEROUS team in the playoffs, if the Titans get players back in the fold (which it sounds like they will).

This is a big test for both, and should be a great game for bettors.

Read more about this game in our Thursday Night Football Best Odds & Bets guide.

Saturday, Dec. 25

Cleveland Browns (7-7) at Green Bay Packers (11-3), 4:30 p.m. EDT (NFL Network and fubo.TV)

The Browns had to play Monday because of the old COVID-19 protocols, and were without their top two quarterbacks. Baker Mayfield should be back here, but this is a tough spot for Cleveland, on short rest, against the NFC’s top seeded team. It will be interesting to see how the last second loss affects the team this week.

Green Bay did just enough (that has happened a lot) to hold off a backup QB and the Ravens on the weekend, and will be heavy favorites here to keep hold of the top spot in the NFC. Can this high-wire act continue for six more weeks?

Indianapolis Colts (8-6) at Arizona Cardinals (10-4), 8:15 p.m. EDT (NFL Network and fubo.TV)

For the second time in a row, the Indianapolis Colts will be the primetime game on a special Saturday Night Football contest against a top contender. This time, the Colts will head to the desert to take on the Cardinals, who have started to falter and have been struck by injuries.

Jonathan Taylor is not going to win the MVP award, because he is not a quarterback. But he might (is) be the most important player for any team, and I am telling you, this Indy team is going to be VERY DANGEROUS in the playoffs. If the Colts are on the other side of the bracket from the Chiefs, I would pick that to be the AFC Championship game.

Read more about this game in our Saturday Night Football Best Odds & Bets guide.

Sunday, Dec. 26

Buffalo Bills (8-6) at New England Patriots (9-5), 1 p.m. EDT (CBS and fubo.TV)

Did we not just play this game? The 50 m.p.h. winds, Bill Belichick calling just three passing plays all game, the 14-10 masterclass?

Yep, but guess what? That might have been all for naught, because the Patriots could not keep their winning streak going, and come into this game just a game ahead of the Bills in the AFC East standings.

That means Buffalo can erase the head to head tiebreaker, and move even with the Pats, if the Bills can win on the road. Can they? You would hope they are better prepared, and they will be getting points here.

LA Rams (9-4 as of Monday) at Minnesota Vikings (7-7), 1 p.m. EDT (FOX and fubo.TV)

Both of these teams had to play after the weekend, with the Vikings beating Chicago Monday to get into playoff contention, and the Rams hosting a special COVID-19 edition of Tuesday Night Football.

With everything happening around them, both are still in contention for either a playoff berth or a division title. I will tell you one thing, though; this LA team is going to be VERY DANGEROUS in the playoffs.

Detroit Lions (2-11-1) at Atlanta Falcons (6-8), 1 p.m. EDT (FOX and fubo.TV)

That tie with Pittsburgh might (probably will) end up costing the Lions the top pick in the NFL draft next year, but there is no elite quarterback, so does it really matter (of course)?

The Lions are playing much better, and that might be bad news for the Falcons, who probably have to win out now to make the playoffs: one of the teams is going to win nine games. Can Atlanta get over the big loss to San Fran and stay in the race?

LA Chargers (8-6) at Houston Texans (3-11), 1 p.m. EDT (CBS and fubo.TV)

This is a very big line for a Los Angeles team that has been all over the map in 2021. Yes, Justin Herbert is a star (and could be VERY DANGEROUS in the playoffs), but the Chargers have lost games that they shouldn’t have at times when they really couldn’t.

Like this week: LA NEEDS to win this game to stay ahead of the pack in the AFC playoff race. Houston has been a little bit like the Chargers (obviously a much crappier version): the Texans have not been bad in some games in the last six or seven weeks, and could really mess up the Chargers here. 

Jacksonville Jaguars (2-12) at New York Jets (3-11), 1 p.m. EDT (CBS and fubo.TV)

How big is this game for the NFL draft order in 2022? MASSIVE!

If the Jaguars can pick up this huge loss here, they can start planning on picking very early in the draft. If they blow it and pick up a win, the Jets then move ahead of them in the draft order (head to head). 

I have said this before, and I will say it again: why would you POSSIBLY bet this game? If you told me I could use your money to bet it, I would tell you to save it and go buy someone (Me) a present.

Baltimore Ravens (8-6) at Cincinnati Bengals (8-6), 1 p.m. EDT (CBS and fubo.TV)

It is amazing that this game may be for the AFC North title. Except that it might not be. The Bengals still have to play the Chiefs and Browns, while the Steelers play the Ravens and Browns. 

But this game is HUGE for the playoff race in the AFC. Baltimore was cruising until injuries absolutely crushed the team, and now is hanging on for dear life. Cincinnati picked up a massive hard fought win in Denver, and can now move to the top of the division with a victory. 

I honestly have very little feel for this game. I would probably back the Bengals because they are healthier. 

New York Giants (3-11) at Philadelphia Eagles (6-7 as of Monday), 1 p.m. EDT (FOX and fubo.TV)

This is a nothing game for the Giants, who stink and would be better off losing out to get some decent picks, IF SOMEONE KNEW HOW TO DRAFT. But that is not the case with New York, so maybe the Giants should just try to play spoiler.

Depending on how the Tuesday night game went, Philly could get to 8-7 with games left against Washington and Dallas. If (IF) the Eagles get in the playoffs, I am not sure I would want to play them: they have overachieved all season, and could be VERY DANGEROUS. They might get blown out, too.

Tampa Bay Buccaneers (10-4) at Carolina Panthers (5-9), 1 p.m. EDT (FOX and fubo.TV)

Tampa Bay might be in trouble. The Bucs are banged up, which is nothing new in 2021. But at some point, it reaches critical mass, and those injuries can’t be overcome. A 9-0 shutout loss to the Saints might have been a blinking warning sign for anyone thinking of taking this team in the playoffs. But they still have Tom Brady.

Carolina stinks. The Panthers are (obviously) too reliant on Christian McCaffrey, and have been awful without him. It would behoove the team to lose out (which might happen WITHOUT them tanking on purpose) and get Kenny Pickett in next season. I can’t see them putting up much of a fight here. 

Chicago Bears (4-10) at Seattle Seahawks (5-8),  4:05 p.m. EDT (FOX and fubo.TV)

The only reason this game is in the late window is because it is in Seattle. I can’t imagine any neutrals watching this game, with the two other late window contests both for potential playoff places.

Chicago fans won’t watch, because it might be a violation of the Geneva Convention to have to sit through any more of this torture in 2021. Seattle fans might watch, if only to see the final few games of Russell Wilson in a Seahawks’ uniform. 

Denver Broncos (7-7) at Las Vegas Raiders (7-7),  4:25 p.m. EDT (CBS and fubo.TV)

The Raiders picked up a MASSIVE win Monday night in the final second, beating a short-handed Cleveland team. It keeps Vegas in the hunt for a playoff spot, and makes this game even bigger.

Teddy Bridgewater is in the concussion protocols, so this could be a huge chance for the Raiders to get above .500: IF they won Monday. Denver’s defense might have to have another monster game to get the Broncos to 8-7 and back in the playoff race.

Pittsburgh Steelers (7-6-1) at Kansas City Chiefs (10-4), 4:25 p.m. EDT (CBS and fubo.TV)

There is nobody, NOBODY, that would have told me a month ago that this game might be to take the lead in the AFC North for the Steelers; or at least to pull within a half game. But here we are, and Pittsburgh just keeps winning games out of nowhere.

This one might be a bridge too far, though: Kansas City is red hot, and now in the driver’s seat for home field advantage. Tell me, who (other than me, of course) would have thought that back when the Chiefs were 3-4. But I never gave up hope on this team, and they are rolling into the playoffs, and of course, they are going to be VERY DANGEROUS (THE MOST DANGEROUS, if I may) in the playoffs.

Washington Football Team (6-7 as of Monday) at Dallas Cowboys (10-4), 8:20 p.m. EDT (NBC and fubo.TV)

Washington plays Philadelphia on a special Tuesday Night Football, COVID-19 edition, so there is not a lot to know about the health etc. of the Football Team. But a win over the Eagles would have Washington in position to make a late playoff run.

It might not matter, though, as Dallas needs to win this game as it searches for the highest seeding possible in the NFC playoffs. This is a VERY DANGEROUS team right now, especially with the defense playing much better. 

Read more about this game in our Sunday Night Football Best Bets & Odds guide.

Monday, Dec. 27

Miami Dolphins (7-7) at New Orleans Saints (7-7), 8:15 p.m. EDT (ESPN and fubo.TV)

Week 16 begins with a bang, and ends with one, as two 7-7 teams will battle it out to see who can get above .500 in squarely into the playoff race in their conference.

Both teams come in with tons of confidence right now: the Dolphins are the hottest team in the NFL, going from 1-7 to 7-7, while the Saints just became the first team to shut out Tom Brady in 255 starts. Both will think they can rely on their defense to win this game, so it will probably be a shootout. I also know one thing: I don’t know if any team would want to play either team in the playoffs, because BOTH could be VERY DANGEROUS. 

Read more about this game in our Monday Night Football Best Odds & Bets guide.

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About Sean Miller
Sean Miller author profile

Sean has been covering sports for the Trenton Times and NJ.com since 2013 and has been writing about sports betting since 2017. He was the beat writer for the Premier League for six years and for the TrentonThunder, the Double-A affiliate of the New York Yankees, now going on his seventh season. Sean also covers local sports (baseball, basketball, football, golf, ice hockey, volleyball, and wrestling) for the Times. He has a UEFA B license (so he knows a little bit about soccer) and is a big fan of the Red team in Manchester.

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